Cytogenetic Study of Fragile Sites and Sister Chromatid Intercrossing.

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  • Arrieta M. I.
    Departamento de Biologia Animal y Genética, Lab. Biologia, Facultad de Ciencias, Universidad del Pais Vasco, Spain
  • Martinez B.
    Departamento de Biologia Animal y Genética, Lab. Biologia, Facultad de Ciencias, Universidad del Pais Vasco, Spain
  • Lobato N.
    Departamento de Biologia Animal y Genética, Lab. Biologia, Facultad de Ciencias, Universidad del Pais Vasco, Spain
  • Criado B.
    Departamento de Biologia Animal y Genética, Lab. Biologia, Facultad de Ciencias, Universidad del Pais Vasco, Spain
  • Nuñez T.
    Departamento de Biologia Animal y Genética, Lab. Biologia, Facultad de Ciencias, Universidad del Pais Vasco, Spain
  • Echarri A.
    Departamento de Biologia Animal y Genética, Lab. Biologia, Facultad de Ciencias, Universidad del Pais Vasco, Spain
  • Lostao C. M.
    Departamento de Biologia Animal y Genética, Lab. Biologia, Facultad de Ciencias, Universidad del Pais Vasco, Spain

抄録

Recently it has been suggested that there is a relationship between fragile sites (FS) in chromosomes and “sister chromatid intercrossing” (SCI). We have analyzed such relationship in a family study of the expression of FS and SCI using TC 199 medium. In a 43.64% of the cases, the observed SCI were located at the same sites of the expressed FS in our sample.<br>The present study supports the suggestion that there could be a relationship between FS and SCI.

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