ラット顎下腺のカテコラミンに対する増齢的応答差に関する研究

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  • Studies on the difference of salivary response to catecholamines in developing rat submandibular gland

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The response of submandibular salivary secretion in rats of several age groups was examined with the administrations of α and β-adrenergic agonists.<BR>Submandibular saliva was collected intraorally from male Sprague-Dawley strain rats of 2 to 8 weeks of age as immature, and 12-15 weeks of age as mature. Noradrenaline (2mg/kg) or phenylephrine (6mg/kg) as α-adrenergic agonists, and isoproterenol (30mg/kg) as β-adrenergic agonist were administered i. p. for collecting saliva.<BR>Results obtained were as follows: The response of salivary secretion, such as salivary volumes, flow rate and protein concentration, in the rats of 7-8 weeks did not significantry differ from that of mature rats. In the response to β-adrenergic agonist by disc electrophoresis, types of secreted proteins in 6-week rats resembled that in mature rats. In the response to a-adrenergic agonists by disc electrophoresis, types of secreted proteins in 7-week rats resembled that in mature rats. However, types of secreted proteins in the rats of 2 to 5 weeks of age were similar to the case of β-adrenergic agonist. The result of analysis of isoelectric focusing indicated that secreted proteins by α-adrenergic agonist in 7-week rats resembled those in mature rats. By chronic noradrenaline (1mg/kg) administration, the growth rates of body weights and submandibular wet weights in 4-week rats were slightly suppressed as compared with those in the control rats.

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