家蚕の消化管運動に関する薬理学的研究  [in Japanese] Pharmacological studies on the gut movements of the silkworm, Bombyx mori.  [in Japanese]

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Abstract

消化管運動の機序を明らかにするために各種薬物を家蚕幼虫の血体腔内に注射して, その影響を調べた。テトロドトキシン注射によって体制筋の麻痺を起した幼虫では, 小腸と直腸の収縮運動が亢進し, 後腸の狭窄部と肛門括約部が弛緩した。腸管内容物は中腸から後腸へ順序よく輸送され, 間歇的に起る排糞運動によって体外に排出された。第12・13神経節摘出や後側神経切断により排糞運動は停止した。テトロドトキン注射蚕にセロトニン, 5-ヒドロキシトリプトファン, イプロニアジド, トラニルシプロミンなどの薬物を投与すると, 中腸運動の亢進が認められた。前2者ではその効果は数時間で消滅するが, 後2者では長時間持続し, それに伴って排糞が促進された。以上の結果から, 後腸運動を支配しているニューロンの一部はテトロドトキシン存在下でも興奮伝達の機能を維持することとセロトニンやその誘導体が腸管運動の調節物質として働くことが示唆された。

When tetrodotoxin was injected into the hemocoel of silkworm larva, the small intestine and the rectum exhibited increased contractile movements and the sphinctors at both ends of the colon and the anus were dilated. The hindgut was filled with an uninterrupted string of food which was continuous with midgut contents on one side and with feces on the other. The gut content was transported normally and evacuated by intermittent strong contrations of the rectum. These contractions were abolished by the extirpation of the terminal ganglion or the severance of the posterior lateral nerves. Serotonin, its precursor (5-hydroxytryptophan) and inhibitors of monoamine oxidase (iproniazid phosphate, tranylcypromine) had stimulative effect on the motor activities of the midgut, when they were injected into the hemocoel of larvae paralyzed with tetrodotoxin. Defecation was enhanced by the inhibitors, whose stimulative effect persisted for much longer period than that of serotonin and its precursor. The results indicated that some of the neurons controlling the hindgut maintained the axonal spike propagation in the presence of tetrodotoxin and that serotonin and its derivative acted as neuromodulators for the gut movements.

Journal

  • The Journal of Sericultural Science of Japan

    The Journal of Sericultural Science of Japan 54(6), 488-494, 1985

    The Japanese Society of Sericultural Science

Codes

  • NII Article ID (NAID)
    130004030815
  • NII NACSIS-CAT ID (NCID)
    AN00190300
  • Text Lang
    JPN
  • Article Type
    journal article
  • ISSN
    0037-2455
  • NDL Article ID
    3060017
  • NDL Source Classification
    RB53(農産--養蚕--蚕)
  • NDL Source Classification
    ZR7(科学技術--農林水産--農産)
  • NDL Call No.
    Z18-343
  • Data Source
    NDL  J-STAGE  JASI 
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