非ステロイド系抗炎症剤のヒト多形核白血球のＯ２｀‐・´産生及びロイコトリエン類生成に及ぼす効果

DOI

書誌事項

タイトル別名
  • The effects of non-steroidal anti-inflammatory drugs on the production of superoxide anion and generation of leukotriens from human polymorphonuclear leukocytes.

抄録

It was reported that some of the non-steroidal anti-inflammatory drugs (NSAID) inhibited arachidonic acid synthesis or suppressed active oxygen production to control inflammations in vivo.<BR>We investigated the effects of NSAID on LTs generation and O-/⋅2 production of polymorphonuclear leukocytes (PMN) separated from human peripheral blood. O-/⋅2 production was detected by CLA-dependent chemiluminescence method and LTs were measured by RP-HPLC. PMN was stimulated by opsonized zymosan (OZ), myristate acetate (PMA) and Ca ionophore A23187 successively separately. Loxoprofen sodium (Loxonin®), Diclofenac sodium (Voltaren®) and Indomethacin (Indacin®) were used as NSAID. The results were as follows :<BR>1) PMN generated only LTB4 when they were stimulated by Ca ionophore A23187. Three units of NSAIDs at the concentration of 25 μg/ml inhibited the generation of LTB4.<BR>2) O-/⋅2 generation by OZ stimulating PMN was not influenced by NSAID. When PMA was used as a stimulant, Loxonin® suppressed the O-/⋅2 generation. But Voltaren® and Indacin® slightly enhanced O-/⋅2 generation. On the contrary, when Ca ionophore A 23187 was used as a stimulant, Voltaren® and Indacin® showed inhibitory effects on O-/⋅2 generation.<BR>These results suggested that NSAID imposed different effects on the function of PMN.

収録刊行物

  • 歯科薬物療法

    歯科薬物療法 10 (1), 51-55, 1991

    日本歯科薬物療法学会

キーワード

詳細情報 詳細情報について

  • CRID
    1390001204730325248
  • NII論文ID
    130004040327
  • DOI
    10.11263/jsotp1982.10.51
  • ISSN
    18844928
    02881012
  • 本文言語コード
    ja
  • データソース種別
    • JaLC
    • CiNii Articles
  • 抄録ライセンスフラグ
    使用不可

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