Fundamental studies of Cefixime(CFIX) in Mxillofacial surgery.

• MOTOJI SHIGEKI

  Department of Mexillofacial Surgery, School of Medicine, Kobe University

• TAKENONO IWAO

  Department of Mexillofacial Surgery, School of Medicine, Kobe University

• OHTSUKA YOSHIKI

  Department of Mexillofacial Surgery, School of Medicine, Kobe University

• NAKASUJI KANAKO

  Department of Mexillofacial Surgery, School of Medicine, Kobe University

• HIRANO FUKI

  Department of Mexillofacial Surgery, School of Medicine, Kobe University

• KOBAYASHI SOUICHIROU

  Department of Mexillofacial Surgery, School of Medicine, Kobe University

• SANO EISAKU

  Department of Mexillofacial Surgery, School of Medicine, Kobe University

• YOSHII TAKASHI

  Department of Mexillofacial Surgery, School of Medicine, Kobe University

• NAKAO KAORU

  Department of Mexillofacial Surgery, School of Medicine, Kobe University

• SHIMADA KEIKICHI

  Department of Mexillofacial Surgery, School of Medicine, Kobe University

Bibliographic Information

Other Title

• Ｃｅｆｉｘｉｍｅ（ＣＦＩＸ）の口腔外科領域における基礎的検討

Abstract

We carried out fundamental studies to evaluate the usefulness of Cefixime (CFIX) in maxillofacial surgery, and obtained the following results.<BR>1) The mean values of concentrations of CFIX after administration of 200mg P.O. to non-fasted patients were 2.42μg/ml (5 hr), 1.79μg/ml (7 hr) in serum, 0.95μg/ml (5 hr), and 0.65μg/ml (7 hr) in blood in wound. Gingival concentrations of CFIX were 0.21-1.17μg/g except 6 N.D.<BR>2) The antibacterial activity of CFIX against 65 Streptococcus sp. clinically isolated was equivalent to those of Ampicillin (ABPC), Cefteram (CFTM), Cefuroxime (CXM) Ofloxacin (OFLX) and superior to that of Cefaclor (CCL) at MIC₈₀, but against 30 Staphyloccoccus sp. CFIX showed inferior antibacterial activity to other antibiotics. Among all antibiotics, CFIX showed the strongest antibactrial activity against arerobic gram-negative organisms.<BR>3) It was considered that CFIX was effective in the treatment of mild and moderate oral infections.

Journal

• ORAL THERAPEUTICS AND PHARMACOLOGY

  ORAL THERAPEUTICS AND PHARMACOLOGY 11 (1), 1-8, 1992

  JAPANESE SOCIETY OF ORAL THERAPEUTICS AND PHARMACOLOGY

Keywords

• Cefixime
• blood in wound
• Oral infections

Details

• CRID: 1390001204728218496
• NII Article ID: 130004040346
• DOI: 10.11263/jsotp1982.11.1
• ISSN: 18844928
• ISSN: 02881012
• Web Site: https://search.jamas.or.jp/link/ui/2020312854
• Text Lang: ja
• Data Source:
  • JaLC
  • CiNii Articles
• Abstract License Flag: Disallowed