歯科・口こう外科領域感染症に対するＣ‐ＡＭＯＸの基礎的・臨床的検討

DOI

書誌事項

タイトル別名
  • Fundamental and clinical studies of long acting amoxicillin granules (C-AMOX) in the infection in the field of oral and maxillofacial surgery.

抄録

Long acting amoxicillin granules (C-AMOX), a newly developed presentation of amoxicillin (AMPC), maintains an effective blood level for an extended period. The following results were obtained from fundamental and clinical studies of C-AMOX.<BR>Serum and gingiva levels of AMPC were measured in 15 patients at 1, 2, 3, 4, and 6 (Patient 5) hours. Serum levels were 2. 34, 3. 07, 4. 23, 3.28μg/ml and 1.18μg/ml respectively, and gingiva levels were 0. 20, 0. 31, 0.54, 0.80μg/g and 0.15μg/g respectively.<BR>One-hundred and forty four patients with oral and maxillofacial infections containing maxillary or mandibular osteitis were treated with C-AMOX. Clinical efficacy was assessed according to the criteria of numerical judgement established by the Japanese Society of Oral Surgery (1973) and also by the global evaluation of the clinician. In numerical judgement there were 24 excellent cases, 82 good cases and 22 poor cases (efficacy ratio : 82.8 %) . The clinician's assessment was 22 excellent cases, 79 good cases, 30 fair cases and 4 poor cases (efficacy ratio: 74.8 %) .<BR>Although slight side effects, diarrhea, nausea, headache and flare of face were observed, both treatments were completed without problem. C-AMOX therapy (b. i, d.) showed good prolonged tissue levels and satisfactory clinical results.

収録刊行物

  • 歯科薬物療法

    歯科薬物療法 3 (1), 92-116, 1984

    日本歯科薬物療法学会

キーワード

詳細情報 詳細情報について

  • CRID
    1390282679711399296
  • NII論文ID
    130004040568
  • DOI
    10.11263/jsotp1982.3.92
  • ISSN
    18844928
    02881012
  • 本文言語コード
    ja
  • データソース種別
    • JaLC
    • CiNii Articles
  • 抄録ライセンスフラグ
    使用不可

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