アミジノ-L-プロリンの目尻の小じわに対する改善効果 Effects of Amidino-L-proline on Fine Wrinkles at the Eye Corners

Access this Article

Author(s)

Abstract

角層保水効果および角層柔軟化効果を有する, アミジノ-L-プロリン (ALP) を配合した処方の, 目尻の小じわに対する改善効果を, ALPのみを除いたプラセボと比較した。健常人女性40名の目尻に5%ALP配合処方もしくはプラセボを1日2回, 6週間塗布し, 塗布開始前と6週間後に比較検討を行った。その結果, しわの写真基準判定において, プラセボ処方群では変化が認められないのに対し, ALP配合処方群では有意な小じわの改善が認められた。またALP配合処方群のみ, 皮膚弾力性と角層水分量の有意な上昇が認められた。以上の結果より5%ALP配合処方は, 目尻の小じわの改善作用を有することが明らかとなった。(皮膚の科学, 1: 355-362, 2002)

We evaluated effects of a formulation consisting of 5% amidino-L-proline, which has waterholding ability and softening effect on the stratum corneum, on fine wrinkles at the eye corners in Japanese women in comparison with a placebo depleted of amidino-L-proline only. These formulations were applied twice daily for 6 weeks and fine wrinkles was assessed after 6 weeks of treatments. In evaluation using photo standards, a significant improvement of fine wrinkles was observed in the amidino-L-proline group in contrast to no change in the placebo group. This improvement of fine wrinkles was accompanied by significant increases in both skin elasticity and water content of the stratum corneum. These results indicate that the formulation consisting of 5% amidino-L-proline is useful in reducing the fine wrinkles at the eye corners. Skin Research, 1: 355-362, 2002

Journal

  • Hifu no kagaku

    Hifu no kagaku 1(5), 355-362, 2002

    Meeting of Osaka Dermatological Association/Meeting of Keiji Dermatological Association

Codes

Page Top