Crystal Structures of Mammalian Xanthine Oxidoreductase Bound with Various Inhibitors: Allopurinol, Febuxostat, and FYX-051

• Okamoto Ken

  Department of Medical and Biological Chemistry, Graduate School of Medicine, Nippon Medical School

• Nishino Takeshi

  Department of Medical and Biological Chemistry, Graduate School of Medicine, Nippon Medical School

抄録

Xanthine oxidoreductase (XOR) catalyzes the reaction of hypoxanthine to xanthine and of xanthine to uric acid. Inhibitors of XOR can thus decrease the concentration of uric acid in serum. Crystal structures of XOR bound with various inhibitors reveal that inhibitors can be categorized into three types, i.e. mechanism-based, structure-based, and hybrid types.<br>

収録刊行物

• 日医大誌

  日医大誌 75 (1), 2-3, 2008

  日本医科大学医学会

キーワード

• General Medicine

詳細情報

• CRID: 1390282680072756096
• NII論文ID: 130004057313
• DOI: 10.1272/jnms.75.2
• ISSN: 13473409
• ISSN: 13454676
• Web Site: http://www.jstage.jst.go.jp/article/jnms/75/1/75_1_2/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2008214929
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
  • KAKEN
• 抄録ライセンスフラグ: 使用不可