Practical Synthesis of Glaziovianin A, a Cytotoxic Isoflavone, and Its <i>O</i><sup>7</sup>-Propargyl Analogue

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Author(s)

    • Hayakawa Ichiro
    • Department of Chemistry, Faculty of Pure and Applied Sciences, University of Tsukuba
    • Shioda Shuya
    • Department of Chemistry, Faculty of Pure and Applied Sciences, University of Tsukuba
    • Ikedo Akiyuki
    • Department of Chemistry, Faculty of Pure and Applied Sciences, University of Tsukuba
    • Kigoshi Hideo
    • Department of Chemistry, Faculty of Pure and Applied Sciences, University of Tsukuba

Abstract

Glaziovianin A and its <i>O</i><sup>7</sup>-propargyl analogue are potent cytotoxic isoflavones. We found that the <i>O</i><sup>7</sup>-propargyl analogue completely arrested cell-cycle progression. We have achieved the large-scale synthesis of glaziovianin A and its <i>O</i><sup>7</sup>-propargyl analogue for further in vivo experimentation.

Journal

  • Bulletin of the Chemical Society of Japan

    Bulletin of the Chemical Society of Japan 87(4), 544-549, 2014

    The Chemical Society of Japan

Codes

  • NII Article ID (NAID)
    130004059109
  • Text Lang
    ENG
  • ISSN
    0009-2673
  • Data Source
    J-STAGE 
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