前頭部紡錘波および中心・頭頂部紡錘波の発達過程とその意義  [in Japanese] Developmental Characteristics of Frontal Spindle and Centro-Parietal Spindle.  [in Japanese]

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Abstract

3~25歳の被験者56名を対象に, 睡眠第2段階に出現する睡眠紡錘波の周波数分析を行い, 中心・頭頂部と前頭部紡錘波に分けて, ピーク周波数とそのパワーの年齢による変化について検討した. 中心・頭頂部紡錘波の周波数はα波同様年齢とともに増加し, 10代後半にはほぼ14Hzに至るが, パワーには大きな変化はみられなかった. 前頭部紡錘波は年少時に最大であったパワーが10代までに急減し, 思春期には周波数が著明に増加し12Hz台となる. こうした変化はGABA系ニューロンを含む皮質および視床皮質路の各々の紡錘波の発現機構の発達を反映するものと思われる. 睡眠紡錘波は以前より乳幼児期の中枢神経系発達の指標に用いられてきたが, 異なる発達過程を示す上記二種類の紡錘波を分けて取り扱うことで, 特に思春期前後の中枢神経系の変化を知る上でも重要な指標になると考えた.

The frequency and power of EEG sleep spindles during sleep stage 2 were analysed in 56 subjects between the age of 3 to 25 years in order to define the maturational pattern of two types of spindles. Although 24 of the 56 subjects were medicated with a single anticonvulsant, there was no remarkable difference in spindle maturation patterns between the subjects who received monotherapy and unmedicated subjects. The frontal spindles matured differently than centro-parietal spindles. The frequency of centro-parietal spindles developed gradually with age, whereas frontal spindles matured with a rather sudden increase of frequency during puberty. Although the power of centro-parietal spindles showed little changes with age, the power of frontal spindles declined remarkably during the first decade and settled down to a constant level after puberty.The developmental characteristics of these two kinds of spindles may reflect a difference in synchronicity of the thalamo-cortical pathway maturation including the inhibitory system. Both centroparietal spindles and frontal spindles tended to develop slightly earlier in females than in males. The lag of spindle maturation in males might implicate developmental precedence in females. Separate observation of these two types of spindles is necessary for better understanding of sleep spindles as an indicator of central nervous system development.

Journal

  • NO TO HATATSU

    NO TO HATATSU 28(5), 409-417, 1996

    THE JAPANESE SOCIETY OF CHILD NEUROLOGY

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