グラム陰性桿菌敗血症の抗生剤療法に関する研究, Tobramycin とその併用療法の検討 STUDIES ON CHEMOTHERAPY FOR SEPTICEMIA DUE TO GRAM NEGATIVE RODS : COMBINATION CHEMOTHERAPY WITH TOBRAMYCIN

Access this Article

Author(s)

Abstract

Tobramycin was investigated especially in the view of its therapeutic use for septicemia due to gram negative rods, and the following results were obtained.<BR>1. The antibacterial activity of tobramycin against <I>P. aeruginosa</I> was 2 to 4 times stronger than that of gentamicin.<BR>2. Tobramycin was almost same as gentamicin in activity against <I>S. aureus, E. coli, Klebsiella</I> and <I>Enterobacter</I>, but it was less than gentamicin against Serratia.<BR>3. Tobramycin showed a good sensitivity against <I>Salmonella</I> and <I>Listeria monocytogenes</I>, but resistant to <I>Bacteroides fragilis</I>.<BR>4. A good in vitro synergic action of both bacteristatic and bactericidal was observed in <I>Klebsiella</I> with combination of tobramycin and cephalothin, and it was observed at the concentration of more than 0.39 μg/ml or at least 0.2μg/ml of tobramycin.<BR>5. Tobramycin was given to 4 cases of septicemia due to gram negative rods, and effective response was observed in each one case with <I>Klebsiella</I> or <I>P. aeruginosa</I>. It was failure in one case with E. colt to which both tobramycin and gentamicin were resistant, and it was unevaluable in one case with <I>P. aeruginosa</I>.<BR>6. In 2 cases with <I>P. aeruginosa</I>, the causative organisms were isolated during the administration of gentamicin at 120 and 160 mg per day, although bath organisms were sensitive (MIC : 3.13 μg/ml) to the drug.

Journal

  • CHEMOTHERAPY

    CHEMOTHERAPY 23(3), 970-975, 1975

    Japanese Society of Chemotherapy

Codes

  • NII Article ID (NAID)
    130004070843
  • NII NACSIS-CAT ID (NCID)
    AN00186653
  • Text Lang
    UNK
  • ISSN
    0009-3165
  • NDL Article ID
    1589783
  • NDL Source Classification
    SC191(感染症)
  • NDL Source Classification
    ZS47(科学技術--医学--治療医学・看護学・漢方医学)
  • NDL Call No.
    Z19-42
  • Data Source
    NDL  J-STAGE 
Page Top