グラム陰性桿菌敗血症の抗生剤療法に関する研究, Tobramycin とその併用療法の検討 STUDIES ON CHEMOTHERAPY FOR SEPTICEMIA DUE TO GRAM NEGATIVE RODS : COMBINATION CHEMOTHERAPY WITH TOBRAMYCIN
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Tobramycin was investigated especially in the view of its therapeutic use for septicemia due to gram negative rods, and the following results were obtained.<BR>1. The antibacterial activity of tobramycin against <I>P. aeruginosa</I> was 2 to 4 times stronger than that of gentamicin.<BR>2. Tobramycin was almost same as gentamicin in activity against <I>S. aureus, E. coli, Klebsiella</I> and <I>Enterobacter</I>, but it was less than gentamicin against Serratia.<BR>3. Tobramycin showed a good sensitivity against <I>Salmonella</I> and <I>Listeria monocytogenes</I>, but resistant to <I>Bacteroides fragilis</I>.<BR>4. A good in vitro synergic action of both bacteristatic and bactericidal was observed in <I>Klebsiella</I> with combination of tobramycin and cephalothin, and it was observed at the concentration of more than 0.39 μg/ml or at least 0.2μg/ml of tobramycin.<BR>5. Tobramycin was given to 4 cases of septicemia due to gram negative rods, and effective response was observed in each one case with <I>Klebsiella</I> or <I>P. aeruginosa</I>. It was failure in one case with E. colt to which both tobramycin and gentamicin were resistant, and it was unevaluable in one case with <I>P. aeruginosa</I>.<BR>6. In 2 cases with <I>P. aeruginosa</I>, the causative organisms were isolated during the administration of gentamicin at 120 and 160 mg per day, although bath organisms were sensitive (MIC : 3.13 μg/ml) to the drug.
CHEMOTHERAPY 23(3), 970-975, 1975
Japanese Society of Chemotherapy