Pipemidic acidの体内動態にかんする研究:Macro-autoradiography法による検討ならびにそれを用いての定量成績 STUDIES ON TISSUE DISTRIBUTION OF PIPEMIDIC ACID:QUALITATIVE AND QUANTITATIVE ANALYSIS BY MACRO-AUTORADIOGRAPHY

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Author(s)

    • 斉藤 篤 SAITO ATSUSHI
    • 東京慈恵会医科大学第三内科学教室 Department of Internal Medicine, The Jikei University, School of Medicine
    • 大森 雅久 OMORI MASAHISA
    • 東京慈恵会医科大学第三内科学教室 Department of Internal Medicine, The Jikei University, School of Medicine
    • 柴 孝也 SHIBA KOYA
    • 東京慈恵会医科大学第三内科学教室 Department of Internal Medicine, The Jikei University, School of Medicine
    • 上田 泰 UEDA YASUSHI
    • 東京慈恵会医科大学第三内科学教室 Department of Internal Medicine, The Jikei University, School of Medicine

Abstract

<SUP>14</SUP>C-Pipemidic acid was administered to male dd mice weighing about 20 g at a single oral dose of 0.5 mg (5.5 μCi) per body, and its distribution was examined by periodic macro-autoradiography followed by a so-called tissue scanning method, in which optical densities of macro-autoradiograms were scanned with a computerized auto-scanning microscope photometer. The results obtained were as follows.<BR>1. <SUP>14</SUP>C-Pipemidic acid administered orally showed good distribution to various tissues except for the central nervous system such as cerebrum, cerebellum and spinal cord, and its concentrations were extremely high in kidneys (medulla>cortex) and liver followed by parotid, myocardium, skin, skeletal muscle, etc. The concentrations in lung and spleen were as high as those in blood.<BR>2. The concentrations of <SUP>14</SUP>C-pipemidic acid in the foetuse were as high as those in placenta, i. e. maternal blood.<BR>3. <SUP>14</SUP>C-Pipemidic acid was rapidly distributed in high concentrations to an acute inflammatory area with cell infiltration in the experimental pyelonephritic mouse kidney, and remained there evidently 4 hours later. However, its distribution to a necrotic area of the kidney was found to be low.<BR>4. In macro-autoradiograms prepared later than 4 hours after administration of <SUP>14</SUP>C-pipemidic acid, darkend areas were found restrictedly in the peritoneal cavity, especially in liver and the inside of intestinal tracts, suggesting the presence of the enteric-hepatic circulation of the drug. Remains of <SUP>14</SUP>C-pipemidic acid in mucous membranes corresponding to glandular stomach were also observed 24 hours after administration.<BR>5. <SUP>14</SUP>C-Pipemidic acid showed an affinity for bones and cartilages, and remained there at high concentrations even 6 hours later. However, it disappeared almost completely from those osteochondral tissues in macro-autoradiograms prepared 24 hours after single oral administration.

Journal

  • CHEMOTHERAPY

    CHEMOTHERAPY 23(9), 2685-2692, 1975

    Japanese Society of Chemotherapy

Codes

  • NII Article ID (NAID)
    130004070874
  • NII NACSIS-CAT ID (NCID)
    AN00186653
  • Text Lang
    UNK
  • ISSN
    0009-3165
  • NDL Article ID
    1617736
  • NDL Source Classification
    ZS47(科学技術--医学--治療医学・看護学・漢方医学)
  • NDL Call No.
    Z19-42
  • Data Source
    NDL  J-STAGE 
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