Pipemidic acidの毒性学的研究

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タイトル別名
  • TOXICOLOGICAL STUDIES ON PIPEMIDIC ACID
  • Pipemidic acid ノ ドクセイガクテキ ケンキュウ 3 イヌ ニ
  • III. SUBACUTE AND CHRONIC TOXICITY STUDIES IN DOGS
  • 第3報 イヌにおける亜急性ならびに慢性毒性試験

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In the subacute toxicity test, mild ataxia, a decrease in body weight and a drop in the plasma albumin level were observed in the group of 800 mg/kg/day early in dosing term, but no abnormalities in the group of 400 mg/kg/day. The toxic signs observed in the group of 800 mg/kg/day disappeared in 3 weeks in spite of continuous drug administration. A slight dilatation of uriniferous tubules was detected by the histopathological examination in 2 of 4 dogs of the group of 800 mg/ kg/day, though abnormalities were not observed in urinalysis and blood analysis.<BR>In the chronic toxicity test, no abnormalities were detected in various checked items except for a mild and focal dilatation of uriniferous tubules observed in 1 or 2 dogs of the all dosages groups, and a slight elevation in the plasma glutamic pyruvic transaminase level observed in 1 dog of the 400 mg/kg/day group.<BR>From these results, it may be suggested that the oral toxicity of PPA is mild in beagles at relatively high doses.

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