CeftezoleとCefazolinの肺炎に対する薬効比較に関する臨床的研究

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  • CLINICAL STUDIES OF EFFICACY COMPARISON BETWEEN CEFTEZOLE AND CEFAZOLIN IN PNEUMONIA
  • Ceftezole ト Cefazolin ノ ハイエン ニ タイスル ヤッコ

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The present authors have carried out a double blind test on the patients of pneumonia hospitalized in 23 institutions as indicated in Table 1, to compare clinical effects of ceftezole (CTZ) with those of cefazoin (CEZ). Each drugs was administered intramuscularly at a daily dose of 2 g for 7-14 days, and both therapeutic efficacy and utility were investigated by comparison.<BR>1. Prescribed dose of the drug was administered for 7-14 days and transfer of chest X-ray finding could be judged in 117 cases of pneumonia. Comparison was made between two drugs of CTZ and CEZ, and the following conclusions were obtained.<BR>1) No significant difference was observed in the therapeutic effects on 7th or 14th day after administration between 53 cases of CTZ group and 64 cases of CEZ group.<BR>2) No significant difference was shown between the utility of two drugs in 117 cases of pneumonia.<BR>2. Investigation was performed on 167 cases, excluding the cases of whom a bacterial pneumonia was suspected at first visit and a prescribed treatment was commenced, however an against-rule or non-objective disease was confirmed distinctly after the examination completion. As a result, no significant difference was demonstrated in therapeutic effects between two drugs.<BR>3. No difference was noticed between the side-effects of two drugs in total 182 cases including the above 117 cases.

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