S-1170の基礎および臨床的検討 LABORATORY AND CLINICAL STUDIES ON CS-1170

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Abstract

1) Sensitivity of 5, 4 and 3 strains of<I>E. coli, Serratia marcescens</I>and<I>Pseudomonas aeruginosa isolated</I>from patients, respectively, to CS-1170 was compared with that of cefazolin (CEZ), cephalothin (CET) and ampicillin (ABPC) The antibacterial activity of CS-1170 against<I>E. coil</I>and<I>Serratia marcescens</I>was superior to that of CEZ, CET and ABPC. However, all strains of<I>Pseudomonas aeruginosa</I>were insensitive not only to CS-1170, but also to other three antibiotics.<BR>2) Blood level and urinary recovery of CS-1170 were determined in two patients.<BR>Peaks of blood level by single intravenous injection of 1.0g of CS-1170 and a subsequent intramuscular injection of 0.5g were 78μg/ml at 15 min. and 15.5μg/ml at 30 min., respectively.<BR>Dose was recovered at 77.8% in urine within 2 hours after intravenous injection, and at 111.4% within 4 hours after intramuscular injection.<BR>3) Ten patients other than with mycoplasma infection responded well to CS-1170 therapy.<BR>With regard to haematological findings, erythrocyte counts, haemoglobin and haematocrite decreased in one patient, and eosinophile counts elevated in 2 patients.

Journal

  • CHEMOTHERAPY

    CHEMOTHERAPY 26(Supplement5), 239-244, 1978

    Japanese Society of Chemotherapy

Codes

  • NII Article ID (NAID)
    130004071254
  • NII NACSIS-CAT ID (NCID)
    AN00186653
  • Text Lang
    UNK
  • ISSN
    0009-3165
  • NDL Article ID
    1964875
  • NDL Source Classification
    ZS47(科学技術--医学--治療医学・看護学・漢方医学)
  • NDL Call No.
    Z19-42
  • Data Source
    NDL  J-STAGE 
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