急性へん桃炎,急性気管支炎に対するセファドロキシルとセファレキシンの二重盲検比較試験に対する臨床評価  [in Japanese] CLINICAL EVALUATION OF CEFADROXIL AND CEPHALEXIN ON ACUTE TONSILLITIS AND ACUTE BRONCHITIS BY DOUBLE BLIND METHOD  [in Japanese]

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Abstract

急性扁桃炎, 急性気管支炎に対するCefadroxil (以下, CDXと略す) とCephalexin (以下, CEXと略す) の治療効果と副作用を比較検討することを目的として, CDX1日750mg (分3), CEX1日1,000mg (分4) それぞれ6日間経口投与し, 治療効果, 副作用, 有用性の両薬剤間での比較を二重盲検法により行い, 次の結果を得た。<BR>1.急性扁桃炎に対し, CDX750mg/日投与は, CEX1,000mg/日投与に比し, 5日目の項目別検討 (主治医判定) では, 腫脹, 膿苔で有意に勝る傾向を示し, また, 赤沈充進では, 3, 5日目で有意に勝っていた。さらに, 全般改善度 (主治医判定および委員会判定) で有意に勝っていた。一方, 有効率ではCDX群86.7%, CEX群84.2%とわずかにCDX群が高かった。<BR>2.急性気管支炎に対し, CDX750mg/日投与はCEX1,000mg/日投与に比し, 全般改善度ならびに各症状別改善度においてほぼ伺等もしくはやや上回る成績であった。<BR>3.副作用の出現頻度はCDX投与群がCEX投与群に比し少なかったが, 有意差は認められなかった。<BR>4.有用性については急性扁桃炎, 急性気管支炎ともに両薬剤群間に有意差は認められなかった。

For the purpose to compare the clinical efficacy and side effect of cefadroxil (abbreviated hereinafter as CDX) and cephalexin (abbreviated hereinafter as CEX) in acute tonsillitis and acute bronchitis, CDX and CEX were administered orally for 6 days at the daily dose of 750 mg (divided into 3) and 1, 000 mg (divided into 4) respectively, and clinical efficacy, side effect and utility were compared between two drugs by double blind method, and the following results were obtained.<BR>1. In acute tonsillitis, CDX (daily dose of 750 mg) tended to be superior significantly on swelling and pus fur by the examination (judged by physician in charge) on 5 th day of administration in comparison with CEX (daily dose of 1, 000 mg), and CDX was superior significantly to CEX in erythrocyte sedimentation rate on 3 rd and 5 th day. Furthermore, CDX was superior significantly in general improvement (judged by both physician in charge and committee). On the other hand, in the utility rate, CDX group showed to be slightly higher than CEX, as the rate was 86.7% in CDX group while 84.2% in CEX group.<BR>2. In acute bronchitis, CDX administration (daily dose of 750 mg) was almost equal or slightly superior on general improvement and each symptom improvement in comparison with CEX administration (daily dose of 1, 000 mg).<BR>3. Frequency of side effects was less in CDX group than in CEX group, though no significant diference was noticed.<BR>4. Utility of the drug showed no significant difference between two drug groups both in acute tonsillitis and acute bronchitis.

Journal

  • CHEMOTHERAPY

    CHEMOTHERAPY 29(1), 30-47, 1981

    Japanese Society of Chemotherapy

Codes

  • NII Article ID (NAID)
    130004071542
  • NII NACSIS-CAT ID (NCID)
    AN00186653
  • Text Lang
    JPN
  • ISSN
    0009-3165
  • NDL Article ID
    2341626
  • NDL Source Classification
    SC651;SD0
  • NDL Source Classification
    ZS47(科学技術--医学--治療医学・看護学・漢方医学)
  • NDL Call No.
    Z19-42
  • Data Source
    NDL  J-STAGE 
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