尿路感染症に対するAM-715の臨床的検討

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タイトル別名
  • A CLINICAL STUDY ON AM-715 IN URINARY TRACT INFECTIONS
  • ニョウロ カンセンショウ ニ タイスル AM 715 ノ リンショウテキ ケン

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A new orally active, chemotherapeutic agent AM-715 was studied clinically in the urological field, and the following conclusions were obtained.<BR>1) AM-715 was administrated orally, as a rule, at the dosage of 300mg or 600mg per day for 3 or 5 days to 60 cases of urinary tract infections and the efficacy was evaluated in 50 cases.<BR>2) Overall clinical efficacy rate was proved in 100% of 28 patients with acute simple cystitis, while 81.8 % of 22 patients with chronic complicated U. T. I.<BR>3) Bacteriologically, 50 out of 55 strains (90.9 %) were eradicated. Especially, all of 5 strains of S. faecalis, 5 out of 6 strains of P. aeruginosa, 17 out of 20 strains resistant to NA and 18 out of 19 strains resistant to PPA were eradicated.<BR>4) No adverse reaction was observed. Deterioration in laboratory findings was observed in one case as slight elevation of serum BUN.<BR>From the above results, AM-715 would be a useful oral drug in the treatment of urinary tract infections.

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