女子急性単純性ぼうこう炎における抗菌剤治療効果のｄｏｓｅ　ｒｅｓｐｏｎｓｅに関する研究　　シノキサシンにおける検討

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  • A DOSE-RESPONSE STUDY ON THE THERAPEUTIC EFFECT ON ACUTE SIMPLE CYSTITIS IN WOMEN: EXAMINATION OF CINOXACIN
  • ジョシ キュウセイ タンジュンセイ ボウコウエン ニ オケル コウキンザイ チ

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A dose response study on therapeutic effect of cinoxacin (CINX) on acute simple cystitis in women was performed by a double blind method.<BR>(1) Urinary concentrations of CINX after 10-12 hours in 6 healthy male volunteers were 20 ± 4, 9 ± 2, 3 ± 2 and 1 ± 1 μg/ml for a dose of CINX 400, 200, 100 and 50 mg respectively.<BR>(2) The major part of isolates from urine in the patients was E. coli, and 98.2%of those E. coli was less than 3.13 μg/ml in the MIC values.<BR>6 percents of the clinical causative organisms were Gram (+) cocci, and the MIC values of those were higher than 800 μg/ml.<BR>(3) Overall clinical efficacy (effective rate) was 100, 91, 96 and 91% for the each dose group of 800, 400, 200 and 100 mg/day (b. i. d.) of CINX respectively. With the exception of Gram (+) Cocci, clinical efficacy was more higher as 100, 97.6, 98.0 and 97.8% for the each dose group of 800, 400, 200 and 100 mg/day respectively.<BR>And the dose response of CINX showed no significant difference, but considering Gram (+) cocci, the group of 800 mg/day of CINX was seen best dosage in the study.

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