妊娠ハムスターにおける巨細胞の組織化学的研究

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  • Histochemical studies of giant cells inpregnanthamsters

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Histochemical demonstration was carried out of nucleic acids, proteins, polysaccharides, lipids, acid and alkaline phosphatases, esterase, succinate dehydrogenase, and various kinds of hydroxysteroiddehydrogenases in primary and secondary giant cells from hamsters 5.5 to 16 days of pregnancy.Primary and secondary giant cells were classified so according to Orsini's division(1954)<BR>.primary giant cells extending cytoplasmic processes were observed in the decidua near the ecto-placental cone and around the implantation cavity, which later increased in number to form a net-work in the decidua capsularis near the Reichert membrane.Frequently, these giant cells containedthe debris of erythrocytes in the cytoplasm.In the last stages of pregnancy, they became spindle-like in shape and decreased in number.Secondary giant cells, polygonal in shape, appeared abundantlyover the outer surface of the proliferating ectoplacental cone 7.5 days of pregnancy, and they subse-quently constituted the trophospongium.<BR>Both primary and secondary giant cells, including trophospongium cells, always contained a largeamount of RNA and a small amount of acrolein-Schiff positive proteins.Primary giant cells possess-ed a small amount of glycogen granules for the first 12 days of pregnancy and asmall amount oflipid droplets for 8 days, both substances disappearing thereafter.Meanwhile secondary giant cellscontained a small amount of glycogen granules for the first 13 days of pregnancy, and a small amountof lipid droplets for 10 days, which increased thereafter.Both types of giant cells showed a weakactivity of acid phosphatase and of succinate dehydrogenase throughout pregnancy, and a weak ac-tivity of alkaline phosphatase for the first 8 days, which disappeared thereafter.They showed noactivities of esterase nor any kind of various hydroxysteroid dehydrogenases.<BR>From the results stated above, it can be proposed that(1)the hamster giant cells, having thenature of migration and phagocytosis, participate in the implantation of blastocysts and in the en-largement of implantation cavity, and that(2)they do not seem to produce progesterone.

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