Interrelationship of Urinary Growth Hormone Levels, Obesity Index, Growth Velocity, and Bone Maturation: A Study in Groups of 7 and 10 year-old Children

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Urinary GH levels in the first voided urine in the morning were measured in schoolchildren aged 7 y (331 boys and 322 girls) and 10 y (355 boys and 354 girls). Each group had a normal height/weight distribution with average values very similar to those of the Japanese cross-sectional growth standard. Urinary GH levels were inversely correlated with obesity index. Obese children (obesity index ≥20%) had lower urinary GH levels in spite of their greater height and normal growth velocity, and were excluded in further analysis. The average values of urinary GH and growth velocity were similarly less in 10 year-old boys than in other groups. In comparison among sub-groups divided according to bone age, urinary GH level showed a significant decrease at bone age 11.0 y in boys, and in girls it was slightly lower at bone age 9-10 y with the following peak at bone age 11.5 y coinciding with that of growth velocity.<BR>These data show that the physiological decrease of GH secretion leads to the deceleration of growth which is observed as the dip of growth rate immediately before the pubertal growth spurt.

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