猩紅熱の流行を起したT12型A群溶連菌に関する血清疫学的研究

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書誌事項

タイトル別名
  • Seroepidemiological Study on Type T-12 Group A Streptococcus which Caused
  • 猩紅熱の流行を起したT12型A群溶連菌に関する血清疫学的研究--特に,T凝集素による血清疫学の試み
  • ショウコウネツ ノ リュウコウ オ オコシタ T12ガタ Aグン ヨウレンキン
  • An Epidemic of Scarlet Fever in 1973
  • 特に, T凝集素による血清疫学の試み

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抄録

An epidemic of scarlet fever caused by type T-12 group A streptococcus which showed no sensitivity to erythromycine and tetracycline occured in Kakunodate, Akita Prefecture, from October to December in 1973. The morbidity of scarlet fever was 279.5 per100, 000 of population and 85 5 of patients were children 3 to 6 years old. Sera obtained from 331 children in two kidergartens, of which 38 children developed scarlet fever, in the middle of and after the epidemic and sera from 100 healthy inhabitants in this district in 1971 were examined for a seroepidemiological survey on type T-12 group A streptococcus.The obtained results were as follows.<BR>1. Before the epidemic, the geometric mean ASLO titer of sera collected from children 4 to 6 years old was 1: 33.8 and the highest ASLO titer was observed in age group 10 to 12 years of old. ASLO titers of sera from children 3 to 6 years of age in the middle of the epidemic apparently increased higher than those of sera from children 4 to 6 years old before the epidemic. Particularly, ASLO titers of 1:>320 were observed in 47.1% of children whose sera were collected either in the middle of or after the epidemic, as compared with 6 % in sera obtained before the epidemic.<BR>2. Eleven (57.9%) out of 19 children 4 to 6 years old before the epidemic revealed T agglutinin titers of 1: 20 against type T-12 group A streptococcus and the geometric mean titer was 1: 28.2, whereas 80% of sera from children in two kindergartens after the epidemic showed the T agglutinin titers 1:>20 and the geometric mean titer increased remarkably to 1: 365.<BR>3. Significant rises (1: 8) of T agglutinin titer to the type T-12 after the epidemic were detected in 124 (64.9%) out of 191 children whose sera were collected both in the middle of and after the epidemic.<BR>4. The rate at which children in two kindergartens were infected with the type 1-12 streptococcus was estimated as 66.0-84.6 5 on the basis of three indexes of significant rise of the T agglutinin titer, patient with scarlet fever and carrier of the type T-12 streptococcus. About 78.7 to 86.7 5 out of the rate were estimated by the index of the T agglutinin titers. Thus, it may be useful for seroepidemiological surveys on group A streptococci to measure T agglutinin titers against each type T streptococcus in human sera.<BR>5. The rate of inapparent infection with the type T-12 group A streptococcus during this epidemic was estimated as 79.8-84.2%.

収録刊行物

  • 感染症学雑誌

    感染症学雑誌 49 (3), 121-127, 1975

    一般社団法人 日本感染症学会

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