糖尿病における髄液蛋白に関する研究

• 岸谷 正雄

  金沢大学医学部第二内科

書誌事項

タイトル別名

• Total Protein Concentration and Protein Fractions in Diabetic Cerebrospinal Fluid
• 糖尿病性合併症と髄液蛋白濃度及びその分画との関連

抄録

The total protein (TP) concentrations in the cerebrospinal fluid (CSF) and the protein fractions analyzed by disc electrophoresis were evaluated in 54 diabetic patients (27 males and 27 females; average age 47) and 12 normal controls (6 males and 6 females; average age 42). The diabetic complications were classified into neuropathy, retinopathy, nephropathy, and microangiopathy (retinopathy and/or nephropathy).<BR>The mean TP concentration in normals was 26±2mg/dl (mean±SEM). In 23 diabetics without any type of complications, it was 33±2mg/dl, which was significantly higher than the value for the normals (p<0.05) but still within the normal range (mean±2 SD of normals). The concentration in 31 diabetics with complication (s) was 54±7mg/dl, which was significantly higher than the value for the diabetics without complications (p<0.01).<BR>A significant correlation was observed between the TP concentrations and the severity of diabetic retinopathy based on Scott's classification (p<0.01). The levels of TP in diabetics with only neuropathy (n=12) were within the normal range, and those in diabetics with microangiopathy alone (n=3) were significantly elevated. No definite correlation was observed between the levels of average fasting blood glucose over 2 weeks prior to CSF collection and the TP concentrations in the CSF of diabetics.<BR>The densitometric tracing patterns of disc electrophoretograms of CSF proteins revealed 8 fractions: prealbumin (PrA), albumin (A), α-lipoprotein (α-LP), α'-globulin (α'-G), transferrin (Tr), β'-globulin (β'-G), γ'-globulin (γ'-G), and slow α₂-globulin (sα₂-G). The concentrations of the A, α-LP, α'-G, Tr, γ'-G, and sα₂-G fractions were significantly increased in diabetics with complication (s) and were significantly correlated with the severity of diabetic retinopathy. In diabetics with microangiopathy, elevated concentrations of A, α'-G, Tr, γ'-G, and sα₂-G were observed and markedly high levels of Tr and sα₂-G were noticed in diabetics with microangiopathy alone. It was apparent therefore that the elevation of concentrations of the above protein fractions might contribute to the increased TP concentrations in the CSF of diabetics.<BR>The above results suggest that elevated TP concentrations of the CSF in diabetics might occur under the strong influence of diabetic microangiopathy rather than neuropathy, and that the most common pattern in the disc electrophoretograms of CSF total proteins in diabetics with mi croangiopathy is elevated sα₂-G fraction protein.

収録刊行物

• 糖尿病

  糖尿病 23 (7), 685-695, 1980

  一般社団法人 日本糖尿病学会

詳細情報

• CRID: 1390001204909215488
• NII論文ID: 130004114752
• DOI: 10.11213/tonyobyo1958.23.685
• ISSN: 1881588X
• ISSN: 0021437X
• データソース種別:
  • JaLC
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可