劇症１型糖尿病と考えられた症例のインスリン分泌能の経年的検討―７年間の前向き研究―

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タイトル別名
  • Prospective Study of the Capacity of Insulin Secretion of Fulminant Type 1 Diabetic Patients from the Onset of Diabetes.
  • ゲキショウ 1ガタ トウニョウビョウ ト カンガエラレタ ショウレイ ノ インスリン ブンピノウ ノ ケイネンテキ ケントウ : 7ネンカン ノ マエムキ ケンキュウ
  • 7年間の前向き研究

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Dr. Imagawa's group proposed the concept of non-autoimmune fulminant type 1 diabetes citing cases which developed through ketoacidosis, and in which the patient's HbA1c was normal or increased only slightly at the time of outbreak, the auto-antibodies of the pancreatic beta cells were negative and the ability of insulin secretion was markedly lower. At our hospital, over several years, we studied the clinical picture and insulin secretion ability of 7 cases, which met this screening outline of non-autoimmune fulminant type 1 diabetes using glucagon loading tests<BR>In 5 cases in whom glucagon loading tests given during outbreak were examined, the serum CPR of glucagon loading after 6 minutes was below 0.1ng/ml and suggested the complete destruction of pancreatic beta cells at the time of outbreak. Furthermore, glucagon loading tests were administered about every six months after onset and the insulin secretion ability was examined over several years, the longest case being 7 years. In all 6 cases the serum CPR of glucagon loading after 6 minutes was below 0.1ng/ml, and in no case was recognizable recovery of insulin secretion ability seen.

収録刊行物

  • 糖尿病

    糖尿病 46 (3), 211-215, 2003

    一般社団法人 日本糖尿病学会

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