書誌事項
- タイトル別名
-
- Assessment of the Metabolic Trapping Rate of FDG in Rat Brain Using Dual Tracer Autoradiography with 18F-FDG and 14C-FDG
- 18F FDG オヨビ 14C FDG ト ノ Dual Tracerホウ オ モチイタ ラット ノウ トウ タイシャ ヘンカリツ ノ ソクテイ
この論文をさがす
抄録
The dual tracer autoradiography using 18F-FDG and 14C-FDG was applied to the estimation of changes in the metabolic trapping rate in rat brain. Rats were infused with kainic acid (1μg/μL) into the right striatum 3 hours prior to the tracer experiment. 18F-FDG was intravenously injected into the rats, and 14C-FDG was injected 44 minutes after 18F-FDG injection. The rats were decapitated at 1 minute post-injection of 14C-FDG, and frozen brain sections were prepared. The slices were exposed on imaging plate for 1 hour, and 18F-FDG images (45 minutes) were obtained. After the decay of 18F, the same slices were contacted with imaging plate for 1 week, and 14C-FDG images (1 minute) were obtained. Radioactivity concentrations in cerebral cortex at 1 minute and 45 minutes after 18F-FDG injection were determined by the dissection method, the values were used to normalize 18F-FDG and 14C-FDG image. The subtraction image was made by subtracting the normalized 14C-FDG image from the 18F-FDG image. In the results, intrastriatal infusion of kainic acid significantly enhanced the metabolic trapping process of FDG. The dual tracer autoradiography with 18F-FDG and 14C-FDG seems to be useful to assess the metabolic trapping rate of FDG in brain injury.
収録刊行物
-
- RADIOISOTOPES
-
RADIOISOTOPES 54 (12), 587-592, 2005
公益社団法人 日本アイソトープ協会
- Tweet
詳細情報 詳細情報について
-
- CRID
- 1390282679128906368
-
- NII論文ID
- 10017093258
- 130004127622
-
- NII書誌ID
- AN00351589
-
- ISSN
- 18844111
- 00338303
-
- NDL書誌ID
- 7772337
-
- 本文言語コード
- ja
-
- データソース種別
-
- JaLC
- NDL
- Crossref
- CiNii Articles
- KAKEN
-
- 抄録ライセンスフラグ
- 使用不可