PHARMACOKINETICS AND CLINICAL EVALUATIONS ON AZTREONAM IN PERINATAL INFECTIONS IN OBSTETRICS AND GYNECOLOGY
-
- MATSUDA SEIJI
- Department of Obstetrics and Gynecology, Juntendo University School of Medicine Kotoh Hospital Kotoh Hospital
-
- OH KINKI
- Department of Obstetrics and Gynecology, Juntendo University School of Medicine Kotoh Hospital Kotoh Hospital
-
- HIRAYAMA HIROAKI
- Department of Obstetrics and Gynecology, Juntendo University School of Medicine Kotoh Hospital Kotoh Hospital
-
- SHIMIZU TETSUYA
- Department of Obstetrics and Gynecology, Asahikawa Medical College
-
- SENGOKU KAZUO
- Department of Obstetrics and Gynecology, Asahikawa Medical College
-
- HAGA HIROMITSU
- Department of Obstetrics and Gynecology, Asahikawa Red-Cross Hospital
-
- INOUE RYOICHI
- Department of Obstetrics and Gynecology, Asahikawa Red-Cross Hospital
-
- YAMAZAKI TOMOFUMI
- Department of Obstetrics and Gynecology, Kushiro Rosai Hospital
-
- MIZOGUCHI HISATOMI
- Department of Obstetrics and Gynecology, Hokkaido Kenpo (Hokushin) Hospital
-
- TORI-I YUTAKA
- Department of Obstetrics and Gynecology, Hokkaido Monbetsu Hospital
-
- SAGAWA TADASHI
- Department of Obstetrics and Gynecology, Hokkaido Monbetsu Hospital
-
- SAITO SATOSHI
- Department of Obstetrics and Gynecology, Nayoro City General Hospital
-
- FUJIMOTO SEI-ICHIRO
- Department of Obstetrics and Gynecology, School of Medicine, Hokkaido University
-
- MAKINODA SATORU
- Department of Obstetrics and Gynecology, School of Medicine, Hokkaido University
-
- NEGISHI HIROAKI
- Department of Obstetrics and Gynecology, School of Medicine, Hokkaido University
-
- OHKOHCHI TOSHIHIRO
- Department of Obstetrics and Gynecology, School of Medicine, Hokkaido University
-
- HANATANI KAORU
- Department of Obstetrics and Gynecology, School of Medicine, Hokkaido University
-
- SATOH HIROSHI
- Department of Obstetrics and Gynecology, School of Medicine, Hokkaido University
-
- TANAKA TOSHINOBU
- Department of Obstetrics and Gynecology, School of Medicine, Hokkaido University
-
- CHIMURA TETSURO
- Department of Obstetrics and Gynecology School of Medicine, Yamagata University
-
- MORISAKI NOBUYUKI
- Department of Obstetrics and Gynecology School of Medicine, Yamagata University
-
- FUNAYAMA TOHRU
- Department of Obstetrics and Gynecology School of Medicine, Yamagata University
-
- MATSUO MASAKI
- Department of Obstetrics and Gynecology School of Medicine, Yamagata University
-
- CHO NAN-KUN
- Department of Obstetrics and Gynecology, School of Medicine, Showa University
-
- FUKUNAGA KANGO
- Department of Obstetrics and Gynecology, School of Medicine, Showa University
-
- KUNI-I KATSUAKI
- Department of Obstetrics and Gynecology, School of Medicine, Showa University
-
- TAMAYA TERUHIKO
- Department of Obstetrics and Gynecology, School of Medicine, Gifu University
-
- ITOH KUNIHIKO
- Department of Obstetrics and Gynecology, School of Medicine, Gifu University
-
- HIROSE REIKO
- Department of Obstetrics and Gynecology, School of Medicine, Gifu University
-
- YAMADA YOSHITAKA
- Department of Obstetrics and Gynecology, Gifu Prefectual Hospital
-
- HAYASAKI MOTOKI
- Department of Obstetrics and Gynecology, Gifu Municipal Hospital
-
- OKADA KOJI
- Department of Obstetrics and Gynecology, Kyoto Prefectural University of Medicine
-
- YAMAMOTO TAKAO
- Department of Obstetrics and Gynecology, Kyoto Prefectural University of Medicine
-
- YASUDA JINSUKE
- Department of Obstetrics and Gynecology, Kyoto Prefectural University of Medicine
-
- IWASAKU KAZUHIRO
- Department of Obstetrics and Gynecology, National Fukuchiyama Hospital
Bibliographic Information
- Other Title
-
- 産婦人科周産期領域におけるAztreonamの基礎的・臨床的検討
- A STUDY OF AZTREONAM IN THE PERINATAL CO-RESEARCH GROUP
- Aztreonam周産期感染症研究会
Abstract
Pharmacokinetics and clinical studies on an injectable monobactam antibiotic, aztreonam (AZT), were carried out in perinatal infections in obstetrics and gynecology and the obtained results are summarized as follows.<BR>1. Pharmacokinetic study<BR>(1) Upon one-shot intravenous injection of AZT 1 g before delivery, maternal serum concentration of AZT was 89.0 μg/ml immediately after the injection and a half-life (T 1/2) of 0.96 hour was observed. Umbilical-cord serum concentration showed a peak value of 16.5 μg/ml at 1.26 hours after the injection and gradually decreased with a T 1/2 of 1.91 hours. The transfer into amniotic fluid was observed and the peak value of AZT in amniotic fluid reached 12.9 μg/ml at 5.57 hours after the injection and slowly decreased thereafter with a T 1/2 of 4.42 hours. Transfer and disappearance in one-shot 2 g intravenous injection and 1 g intravenous drip infusion (1 hour) of AZT were very similar to the results obtained with the one-shot 1 g intravenous injection.<BR>(2) The residual serum concentration in neonates after one-shot 1 g intravenous injection of AZT to the mother was almost below the detectable limit. Transfer of AZT into milk was scarcely recognized.<BR>2. Clinical studies<BR>(1) AZT was injected to 47 cases with various perinatal infections and it was more than“effective” in 45 cases with an efficacy rate of 95.7%. Also, all the 12 cases to which AZT was administered for prophylaxis of infections showed prophylactic effect. Bacterial eradication was obtained with 25 strains out of 29 aerobic Gram-negative bacteria, but 1 strain “persisted” and for 3 strains results were “unknown”, hence an eradication rate of 96.2% was obtained. However, AZT treatment resulted in a little lower eradication rate against Gram-positive bacteria.<BR>(2) One case (1.3%) of minor degree of urticaria was found as a side effect, and one case each of eosinophilia and elevation of GOT, GPT and Al-P was observed as abnormal laboratory value.<BR>From the above results of pharmacokinetics and clinical evaluation, it has been concluded that AZT is a usejul and highly safe drug in various perinatal infections and prophylaxis.
Journal
-
- The Japanese Journal of Antibiotics
-
The Japanese Journal of Antibiotics 43 (4), 736-753, 1990
Japan Antibiotics Research Association
