Fosfomydnの血中濃度と組織内移行濃度に関する基礎的研究

DOI
  • 古田 茂
    Department of Otolaryngology, School of Medicine, Kagoshima University
  • 福田 勝則
    Department of Otolaryngology, School of Medicine, Kagoshima University
  • 松山 博文
    Department of Otolaryngology, School of Medicine, Kagoshima University
  • 黒野 裕一
    Department of Otolaryngology, School of Medicine, Kagoshima University
  • 深水 浩三
    Department of Otolaryngology, School of Medicine, Kagoshima University
  • 矢野 博美
    Department of Otolaryngology, School of Medicine, Kagoshima University
  • 坂本 邦彦
    Department of Otolaryngology, School of Medicine, Kagoshima University
  • 清田 隆二
    Department of Otolaryngology, School of Medicine, Kagoshima University

書誌事項

タイトル別名
  • Fundamental Studies of Fosfomyein in Otolaryngology

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抄録

Investigations of a new antibiotic, fosfomycin, were conducted. Concentrations in blood and tissues were studied 1 and 2 hours after administration of either capsule or dry syrup fosfomycin.<BR>Two hours after administration of 2g of the dry syrup, the maximum concentration in blood was 8.31μg/ml, 4.51μg/g in palatine tonsil, 3.92μg in the mucous membrane of the maxillary sinus, 3.18μg/ml in maxillary exudate, 5.26μg/g in nasal polyp, 2.72μ/g in inferior turbinates, and 1.94μg/g in the nasal tumor tissue. No measurable concentration was found in exudate of maxillary cyst.<BR>One hour after administration of 1g of syrup, the maximum blood concentration was 5.57μg/ml.<BR>Two hours after administration of a 2g capsule, the concentration was 7.05μg/ml.

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