Fosfomydnの血中濃度と組織内移行濃度に関する基礎的研究
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- 古田 茂
- Department of Otolaryngology, School of Medicine, Kagoshima University
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- 福田 勝則
- Department of Otolaryngology, School of Medicine, Kagoshima University
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- 松山 博文
- Department of Otolaryngology, School of Medicine, Kagoshima University
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- 黒野 裕一
- Department of Otolaryngology, School of Medicine, Kagoshima University
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- 深水 浩三
- Department of Otolaryngology, School of Medicine, Kagoshima University
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- 矢野 博美
- Department of Otolaryngology, School of Medicine, Kagoshima University
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- 坂本 邦彦
- Department of Otolaryngology, School of Medicine, Kagoshima University
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- 清田 隆二
- Department of Otolaryngology, School of Medicine, Kagoshima University
書誌事項
- タイトル別名
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- Fundamental Studies of Fosfomyein in Otolaryngology
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抄録
Investigations of a new antibiotic, fosfomycin, were conducted. Concentrations in blood and tissues were studied 1 and 2 hours after administration of either capsule or dry syrup fosfomycin.<BR>Two hours after administration of 2g of the dry syrup, the maximum concentration in blood was 8.31μg/ml, 4.51μg/g in palatine tonsil, 3.92μg in the mucous membrane of the maxillary sinus, 3.18μg/ml in maxillary exudate, 5.26μg/g in nasal polyp, 2.72μ/g in inferior turbinates, and 1.94μg/g in the nasal tumor tissue. No measurable concentration was found in exudate of maxillary cyst.<BR>One hour after administration of 1g of syrup, the maximum blood concentration was 5.57μg/ml.<BR>Two hours after administration of a 2g capsule, the concentration was 7.05μg/ml.
収録刊行物
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- 耳鼻と臨床
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耳鼻と臨床 28 (2), 232-237, 1982
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詳細情報 詳細情報について
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- CRID
- 1390282680475230720
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- NII論文ID
- 130004132858
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- ISSN
- 04477227
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可