Artificial Compounds Differentially Control Dictyostelium Chemotaxis and Cell Differentiation

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  • Kuwayama Hidekazu
    Graduate School of Life and Environmental Sciences, University of Tsukuba
  • Kikuchi Haruhisa
    Graduate School of Pharmaceutical Sciences, Tohoku University
  • Oshima Yoshiteru
    Graduate School of Pharmaceutical Sciences, Tohoku University
  • Kubohara Yuzuru
    Department of Molecular and Cellular Biology, Institute for Molecular and Cellular Regulation (IMCR), Gunma University

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Differentiation-inducing factor-1 and -2 (DIF-1 and DIF-2) are small lipophilic signal molecules that control both cell differentiation and chemotaxis in the cellular slime mold Dictyostelium discoideum. In this study, we examined the effects of four amide derivatives of DIF-1 on stalk cell differentiation and chemotaxis. The DIF derivatives differentially affected cell differentiation and chemotaxis, suggesting the possible existence of at least three receptors for DIFs: one receptor responsible for stalk cell induction, and two receptors responsible for chemotaxis modulation. Furthermore, our results indicate that DIF derivatives can be utilized to analyze the DIF-signaling pathways.<br>

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