Artificial Compounds Differentially Control Dictyostelium Chemotaxis and Cell Differentiation
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- Kuwayama Hidekazu
- Graduate School of Life and Environmental Sciences, University of Tsukuba
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- Kikuchi Haruhisa
- Graduate School of Pharmaceutical Sciences, Tohoku University
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- Oshima Yoshiteru
- Graduate School of Pharmaceutical Sciences, Tohoku University
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- Kubohara Yuzuru
- Department of Molecular and Cellular Biology, Institute for Molecular and Cellular Regulation (IMCR), Gunma University
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Abstract
Differentiation-inducing factor-1 and -2 (DIF-1 and DIF-2) are small lipophilic signal molecules that control both cell differentiation and chemotaxis in the cellular slime mold Dictyostelium discoideum. In this study, we examined the effects of four amide derivatives of DIF-1 on stalk cell differentiation and chemotaxis. The DIF derivatives differentially affected cell differentiation and chemotaxis, suggesting the possible existence of at least three receptors for DIFs: one receptor responsible for stalk cell induction, and two receptors responsible for chemotaxis modulation. Furthermore, our results indicate that DIF derivatives can be utilized to analyze the DIF-signaling pathways.<br>
Journal
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- Cell Structure and Function
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Cell Structure and Function 36 (1), 21-26, 2011
Japan Society for Cell Biology
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Keywords
Details 詳細情報について
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- CRID
- 1390001204695536000
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- NII Article ID
- 130004137560
- 40019163780
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- NII Book ID
- AA0060007X
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- ISSN
- 13473700
- 03867196
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- NDL BIB ID
- 023442603
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed