Anti-Angiogenesis Activities of Novel Peptide Complexes: Mitochondria-Disruptive 9mer Peptides Conjugated with the Integrin alpha V beta 3-Homing Cyclic RGD Motif

DOI Web Site Web Site PubMed 被引用文献1件 参考文献32件
  • IWASAKI Takashi
    Faculty of Agriculture, Tottori University Faculty of Agriculture, Tottori University
  • YAMAKAWA Minoru
    Insect Mimetics Research Unit, National Institute of Agrobiological Sciences Insect Mimetics Research Unit, National Institute of Agrobiological Sciences
  • ASAOKA Ai
    Insect Mimetics Research Unit, National Institute of Agrobiological Sciences Insect Mimetics Research Unit, National Institute of Agrobiological Sciences
  • KAWANO Tsuyoshi
    Faculty of Agriculture, Tottori University Faculty of Agriculture, Tottori University
  • ISHIBASHI Jun
    Insect Mimetics Research Unit, National Institute of Agrobiological Sciences Insect Mimetics Research Unit, National Institute of Agrobiological Sciences

この論文をさがす

抄録

RGD peptides are popular drug delivery tools in treating integrin αVβ3-expressing malignant tumors and tumor vasculature cells. We investigated the specific delivery and pharmacological potential of enantiomeric mitochondria-disruptive peptides (RLYLRIGRR-NH2, RLRLRIGRR-NH2, ALYLAIRRR-NH2, and RLLLRIGRR-NH2) after conjugation with an integrin αVβ3-homing peptide, cyclic pentameric RGD peptide. The cyclic RGD-conjugated mitochondria-disruptive peptides exhibited specific internalization, apoptosis induction, and cytotoxicity against integrin αVβ3-high-expressing human umbilical vein endothelial cells. Our findings indicate that these novel peptide complexes might prove good anti-angiogenesis reagents.

収録刊行物

被引用文献 (1)*注記

もっと見る

参考文献 (32)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ