Impact of Coexisting Irritable Bowel Syndrome and Non-erosive Reflux Disease on Postprandial Abdominal Fullness and Sleep Disorders in Functional Dyspepsia
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- Futagami Seiji
- Division of Gastroenterology, Department of Internal Medicine, Nippon Medical School
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- Yamawaki Hiroshi
- Division of Gastroenterology, Department of Internal Medicine, Nippon Medical School
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- Shimpuku Mayumi
- Division of Gastroenterology, Department of Internal Medicine, Nippon Medical School
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- Izumi Nikki
- Division of Gastroenterology, Department of Internal Medicine, Nippon Medical School
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- Wakabayashi Taiga
- Division of Gastroenterology, Department of Internal Medicine, Nippon Medical School
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- Kodaka Yasuhiro
- Division of Gastroenterology, Department of Internal Medicine, Nippon Medical School
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- Nagoya Hiroyuki
- Division of Gastroenterology, Department of Internal Medicine, Nippon Medical School
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- Shindo Tomotaka
- Division of Gastroenterology, Department of Internal Medicine, Nippon Medical School
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- Kawagoe Tetsuro
- Division of Gastroenterology, Department of Internal Medicine, Nippon Medical School
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- Sakamoto Choitsu
- Division of Gastroenterology, Department of Internal Medicine, Nippon Medical School
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Abstract
Background/Aims: The association between clinical symptoms and sleep disorders in functional dyspepsia (FD)-overlap syndrome has not been studied in detail.<br> Methods: The subjects were 139 patients with FD, 14 with irritable bowel syndrome (IBS), 12 with nonerosive reflux disease (NERD), and 41 healthy volunteers. Gastric motility was evaluated with the 13C-acetate breath test. We used Rome III criteria to evaluate upper abdominal symptoms, and Self-Rating Questionnaire for Depression (SRQ-D) scores to determine depression status. Sleep disorders were evaluated with Pittsburgh Sleep Quality Index (PSQI) scores.<br> Results: There were no significant differences in age, body-mass index, alcohol intake, and smoking rate between patients with FD alone and those with FD-overlap syndrome. The postprandial abdominal fullness score in patients with FD-NERD-IBS was significantly greater than that in patients with FD-NERD overlap syndrome (p<0.001) or FD alone (p<0.001). The score for the feeling of hunger in patients with FD-NERD-IBS was significantly greater than that in patients with FD alone (p=0.0025), FD-NERD overlap syndrome (p=0.0088), or FD-IBS overlap syndrome (p=0.0057). The heartburn score in subjects with FD-NERD-IBS overlap syndrome was significantly greater than that in subjects with FD alone (p=0.0035) or FD-IBS overlap syndrome (p=0.0026). The Tmax in patients with FD-overlap syndrome or FD alone was significantly higher than that in healthy volunteers. The Pittsburgh Sleep Quality Index score in subjects with FD-NERD-IBS overlap syndrome was significantly greater than that in subjects with FD alone.<br> Conclusion: Symptom scores, such as those for postprandial abdominal fullness, heartburn, and the feeling of hunger, in patients with FD-overlap syndromes are significantly greater than those in patients with FD alone. Further studies are necessary to clarify whether various symptoms are related to sleep disorders in patients with FD-NERD-IBS overlap syndrome.<br>
Journal
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- Journal of Nippon Medical School
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Journal of Nippon Medical School 80 (5), 362-370, 2013
The Medical Association of Nippon Medical School