Inhalation Anesthesia Is Preferable for Recording Rat Cardiac Function Using an Electrocardiogram

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  • Murakami Manabu
    Department of Pharmacology, Hirosaki University, Graduate School of Medicine
  • Niwa Hidetoshi
    Department of Anesthesiology, Hirosaki University, Graduate School of Medicine
  • Kushikata Tetsuya
    Department of Anesthesiology, Hirosaki University, Graduate School of Medicine
  • Watanabe Hiroyuki
    Department of Internal Medicine Division of Cardiovascular and Respiratory Medicine, Akita University School of Medicine
  • Hirota Kazuyoshi
    Department of Anesthesiology, Hirosaki University, Graduate School of Medicine
  • Ono Kyoichi
    Department of Cellphysiology, Akita University School of Medicine
  • Ohba Takayoshi
    Department of Cellphysiology, Akita University School of Medicine

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Abstract

The effects of inhalation anesthesia (2% isoflurane, sevoflurane, or enflurane) and intraperitoneal anesthesia with pentobarbital (65 mg/kg) were compared in rats using an electrocardiogram (ECG) and determination of blood oxygen saturation (SPO2) levels. Following inhalation anesthesia, heart rate (HR) and SPO2 were acceptable while pentobarbital anesthesia decreased HR and SPO2 significantly. This indicates that inhalation anesthesia is more preferable than pentobarbital anesthesia when evaluating cardiovascular factors. Additionally, pentobarbital significantly increased HR variability (HRV), suggesting a regulatory effect of pentobarbital on the autonomic nervous system, and resulted in a decreased response of the baro-reflex system. Propranolol or atropine had limited effects on ECG recording following pentobarbital anesthesia. Taken together, these data suggest that inhalation anesthesia is suitable for conducting hemodynamic analyses in the rat.

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