Kurahamide, a Cyclic Depsipeptide Analog of Dolastatin 13 from a Marine Cyanobacterial Assemblage of <i>Lyngbya</i> sp.

• Arihiro Iwasaki

  Department of Chemistry, Keio University

• Shinpei Sumimoto

  Faculty of Science, University of Ryukyus

• Osamu Ohno

  Department of Chemistry, Keio University

• Shoichiro Suda

  Faculty of Science, University of Ryukyus

• Kiyotake Suenaga

  Department of Chemistry, Keio University

抄録

Kurahamide, a new dolastatin 13 analog, was isolated from a marine cyanobacterial assemblage, consisting mostly of Lyngbya sp. Its gross structure was elucidated by spectroscopic analysis, and the stereochemistries were assigned based on a chiral HPLC analysis of hydrolysis products. Kurahamide strongly inhibited elastase and chymotrypsin in vitro. In addition, kurahamide moderately inhibited the growth of human cancer cells, including HeLa and HL60 cells.

収録刊行物

• Bulletin of the Chemical Society of Japan

  Bulletin of the Chemical Society of Japan 87 (5), 609-613, 2014-02-21

  Oxford University Press (OUP)

キーワード

• General Chemistry

詳細情報

• CRID: 1360565169050354688
• NII論文ID: 130004153298
• DOI: 10.1246/bcsj.20140008
• ISSN: 13480634
• ISSN: 00092673
• Web Site: https://academic.oup.com/bcsj/article-pdf/87/5/609/56276915/bcsj.20140008.pdf
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