少量Ｃｉｓｐｌａｔｉｎ同時併用による頭頚部癌の放射線治療

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  • Combined low dose cisplatin and radiation therapy in advanced head and neck cancer.

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One hundred and twenty-eight patients with advanced head and neck squamous cell carcinoma were entered in to a feasibility stydy of low-dose cisplatin (CDDP) with concurrent radiation therapy. Minimum follow-up time was 1 year. As an intial treatment, the radiotherapy regimen consisted of 1.8-2.0Gy given 5 days a week for 4-5 weeks (40-50Gy), and the CDDP (daily dose of 5mg m2 or 6mg/body, iv) was administered of a loco-ragional major response (complate+partial) within 2 weeks after completion of initial treatment was 95%. Thirty-one patients underwent surgery, and 87 patients had boost radiation (10-25Gy), although 10 patients refused additional treatment. The 1-year relapse-free survival rate for oropharynx (37pts), hypopharynx (11pts), glottis (16pts), and supraglottis (16pts) were 74%, 80%, 62%, and 84%, respectively. The 1-year cause-specific survival for those were 92%, 100%, 100%, respectively, the high response and survival rates obtained.

収録刊行物

  • 頭頸部腫瘍

    頭頸部腫瘍 20 (3), 530-536, 1994

    日本頭頸部癌学会

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