糖尿病性じん症におけるMesangiolysisについて

書誌事項

タイトル別名
  • Mesangiolysis in diabetic glomerulosclerosis.

抄録

Three hundred kidney biopsy specimens and 10 autopsy specimens were reviewed with an attempt to describe diabetic "mesangiolysis (ML)" and to clarify its role in a development of diabetic glomerulosclerosis, especially of intraglomerular microaneurysms and of nodular lesions. ML observed under a light microscope was segmental and centrilobular meshworkmaking, lamellated, acellular or less-cellular amorphous and disorganized lytic lesions of mesangium and was usually accompanied with microaneurysm (88%), formed from dilated capillaries surrounding the mesangiolytic area and with foam cells (51%) located in the periphery of the tufts. The lesion was observed in 41 of 59 specimens (69%) with nodular lesions, compared with only 2 out of 251 specimens (0.8%) without nodular lesions, but in 21 of 310 specimens all of ML, nodular lesions, microaneurysms and foam cells were observed simultaneously. In some cases, however, the "meshworkmaking" or lamellated materials in the mesangiolytic area were hardly distinguished from a small diabetic nodule. The incidence of all these lesions present in diabetic glomeruli were increased in accordance with progression of diffuse lesions and diabetic arteriolosclerosis. From these results, it is suggested that ML, microaneurysms and nodular lesions are coincidental lesions and that ML may be an initial insult in forming microaneurysms and nodular lesions in diabetic glomeruli.

収録刊行物

詳細情報

  • CRID
    1390001204860299008
  • NII論文ID
    130004168991
  • DOI
    10.14842/jpnjnephrol1959.26.367
  • ISSN
    18840728
    03852385
  • PubMed
    6471580
  • 本文言語コード
    ja
  • データソース種別
    • JaLC
    • PubMed
    • CiNii Articles
  • 抄録ライセンスフラグ
    使用不可

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