書誌事項
- タイトル別名
-
- A new type of hereditary glomerulonephritis.
抄録
An unusal familial glomerular disease was found in two siblings. Among the 22 members (11 males, 11 females) of this pedigree, eight were affected by glomerulonephritis and three developed renal failure. In this pedigree, none had auditory or ocular abnormalities. Throuh the clinical course, neither nephrotic syndrome nor hypertention was observed in the two siblings which were examined, however, after 22 months from the discovery of proteinuria, an elder brother needed hemodialysis because of renal failure. The renal histrogical findings concerning these two siblings showed a characteristic lesion of focal glomerulosclerosis and thinning of the glomerular basement membrane. Hyperprolinemia was also observed in these two siblings. This disease was not HLAlinked in the five tested members of this pedigree. The mode of inheritance appeared to be autosomal dominant.
収録刊行物
-
- 日本腎臓学会誌
-
日本腎臓学会誌 26 (8), 1045-1054, 1984
社団法人 日本腎臓学会