各種腎疾患における赤血球および糸球体C3bレセプター(CR1)欠損の意義について  [in Japanese] C3b receptor (CR1) on red blood cell and glomerulus in various glomerular diseases.  [in Japanese]

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Abstract

We examined a total of 102 patients with primary glomerular disease about the C3b receptor using immune adherence hemagglutination (IAHA) method, 2 out of 16 patients with minimal change nephrotic syndrome (MCNS) and 2 out of 13 patients with mesangio-capillary glomerulonephritis (MCGN) showed CR1 deficiency on the red blood cells. There was no difference in the prevalence of CR1 deficiency on red blood cells of normal control (1 out of 53, 1.9%) compared to the 102 patients with the primary glomerular disease. We also examined 23 patients with the secondary glomerular disease, 10 out of 17 with lupus nephritis and 1 out of 4 with Henoch Schönlein purpura nephritis (HSP) also showed CR1 deficiency on the red blood cells. Next we examined the CR1 deficiency in the relatives of the 4 patients with the primary glomerular disease and the patient with HSP nephritis, the deficiency or diminution of CR1 was found in 4 families but no deficiency was found in one case (case 1, MCNS). The defective erythrocyte CR1 reaction was persistent even after these patients had gone into remission without case 1. The reaction of CR1 on erythrocyte (case 1) changed parallel with clinical symptoms and laboratory data. These results imply that the defective erythrocyte reaction found in glomerulonephritis might be caused not only through inheritance but also acquirement. In frozen kidney sections, glomerular CR1 was examined, and then compared with the reaction of erythrocyte CR1 in patients. Among the patients whose erythrocyte were negative by IAHA, two patients with MCNS and one with lupus nephritis showed a high reaction of glomerular CRl and the other three patients (MCGN, lupus nephritis, HSP nephritis) showed a low reaction of glomerular CRl. The results indicate that the expression of CR1 on the glomerulus and the erythrocvte are not parallel

Journal

  • The Japanese Journal of Nephrology

    The Japanese Journal of Nephrology 29(1), 13-19, 1987

    Japanese Society of Nephrology

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