Immunopathological correlations of circulating immune complexes and anti-DNA antibodies to glomerular lesions in systemic lupus erythematosus.
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In 42 renal biopsy specimens from 40 systemic lupus erythematosus (SLE) patients, the glomerular histology and immunofluorescence findings, according to the grades and patterns of IgG deposits, were compared with data for clinical and serological tests including the circulating immune complexes (CIC) and anti-dsDNA antibodies. The levels of CIC measured by solid phase C1q binding assay (SPC1q-IC) were highest in the group showing mesangial and segmental capillary wall IgG deposits, with clinically active symptoms, whereas the CIC by conglutinin binding assay (SPKg-IC) revealed poor correlations. The serum levels of anti-dsDNA antibodies were significantly correlated histologically with both mesangial cell proliferation and karyo rrhexis and/or pycnosis, and by immunofluorescence with the grades of mesangial IgG deposits. These findings suggest that anti-dsDNA antibodies may contribute to the mesangial lesions of lupus nephritis and that SPC1q-IC is related to active renal disease which shows diffuse mesangial and segmental capillary wall IgG deposits.
- The Japanese Journal of Nephrology
The Japanese Journal of Nephrology 29(5), 501-509, 1987
Japanese Society of Nephrology