ヒト腎組織における免疫担当細胞の同定  [in Japanese] The detection of immune cells in human kidney tissues.  [in Japanese]

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Abstract

Renal biopsy specimens from a total of 59 patients with IgAA nephropathy (25 patients), Henoch-Schonlein purpura nephritis (HSPN) (13 patients), mesangial proliferative (non-IgA) glomerulonephritis (13 patients), and minimal change nephrotic syndrome (S patients) were examined for immune cells (macrophages, helper T cells, suppresser T cells, D cells and polymorphonuclear leukocytes) by immunofluorescence. Non-specific esterase (NSE) staining was also used to identify the macrophages, and compared with the identification by monoclonal antibodies. Two monoclonal antibodies (Mo2 and FMC-32) showed similar results on the detection of macrophages, and NSE was less sensitive than the monoclonal antibodies. In IgA nephropathy and HSPN, macrophages were the dominant cells infiltrating the gloeruli. In patients with mesangial proliferative (non-IgA) glomerulonephritis and minimal change nephrotic syndrome, there was no significant difference in glomerular and interstitial populations of immune cells. These findings suggest that macrophages play an important role in the development of IgA nephropathy and HSPN.

Journal

  • The Japanese Journal of Nephrology

    The Japanese Journal of Nephrology 29(6), 607-614, 1987

    Japanese Society of Nephrology

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