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- OIMOMI MUNETADA
- Department of Internal Medicine, Kobe University School of Medicine
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- IGAKI NAOYA
- Department of Internal Medicine, Kobe University School of Medicine
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- NAKAMICHI TSUNEO
- Department of Internal Medicine, Kobe University School of Medicine
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- MASUDA SHOGO
- Department of Internal Medicine, Kobe University School of Medicine
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- MAEDA YUICHIRO
- Department of Internal Medicine, Kobe University School of Medicine
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- HATA FUMIHIKO
- Department of Internal Medicine, Kobe University School of Medicine
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- KITAMURA YOSHIAKI
- Department of Internal Medicine, Kobe University School of Medicine
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- NISHIMOTO SHIGEKI
- Department of Internal Medicine, Kobe University School of Medicine
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- MATSUMOTO SHINICHIRO
- Department of Internal Medicine, Kobe University School of Medicine
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- HATANAKA HIROSHI
- Department of Internal Medicine, Kobe University School of Medicine
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- BABA SHIGEAKI
- Department of Internal Medicine, Kobe University School of Medicine
Abstract
We investigated the usefulness of oral protein loading tests for evaluating renal functional reserve. Healthy subjects and patients with renal impairment were given protein-rich meals to eat after a night's fast (1 g protein/kg body weight). Later, at hougly intervals, the creatinine clearance (Ccr) was measured and the change compared to the previous value (delta Ccr) was estimated. Boiled lean yellowfin tuna was used as the protein source. The largest delta Ccr in the healthy subjects, 34.4 ± 6.0 ml/min, occurred at the second hour after the protein load. There was a significant correlation between the delta Ccr values and the preceding Ccr values. On the basis of these results, the delta Ccr after oral protein loading was considered to reflect the renal functional reserve, and monitoring of delta Ccr appeared to be useful for evaluating the progression of renal impairment.
Journal
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- The Japanese Journal of Nephrology
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The Japanese Journal of Nephrology 30 (9), 1091-1094, 1988
Japanese Society of Nephrology
