Oral protein loading tests in patients with renal impairment.

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We investigated the usefulness of oral protein loading tests for evaluating renal functional reserve. Healthy subjects and patients with renal impairment were given protein-rich meals to eat after a night's fast (1 g protein/kg body weight). Later, at hougly intervals, the creatinine clearance (Ccr) was measured and the change compared to the previous value (delta Ccr) was estimated. Boiled lean yellowfin tuna was used as the protein source. The largest delta Ccr in the healthy subjects, 34.4 ± 6.0 ml/min, occurred at the second hour after the protein load. There was a significant correlation between the delta Ccr values and the preceding Ccr values. On the basis of these results, the delta Ccr after oral protein loading was considered to reflect the renal functional reserve, and monitoring of delta Ccr appeared to be useful for evaluating the progression of renal impairment.


  • The Japanese Journal of Nephrology

    The Japanese Journal of Nephrology 30(9), 1091-1094, 1988

    Japanese Society of Nephrology


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