Effect of the angiotensin converting enzyme inhibitor, captopril, on proteinuria in chronic glomerular disease.

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Author(s)

    • TABEI KAORU
    • Division of Nephrology , Department of Medicine, Jichi Medical School, Tochigi
    • TAKEDA SHIGEYUKI
    • Division of Nephrology , Department of Medicine, Jichi Medical School, Tochigi
    • ANDO YASUHIRO
    • Division of Nephrology , Department of Medicine, Jichi Medical School, Tochigi
    • KUSANO EIJI
    • Division of Nephrology , Department of Medicine, Jichi Medical School, Tochigi
    • ASANO YASUSHI
    • Division of Nephrology , Department of Medicine, Jichi Medical School, Tochigi

Abstract

The antiproteinuric effect of the angiotensin-l-converting enzyme inhibitor, captopril, was studied in 14 patients (10 men and 4 women, age range of 24 to 60 years) with chronic glomerulonephritis in whom IgA nephritis had been confirmed by renal biopsy. Eight of the 14 patients had received antihypertensive drugs such as calcium channel blockers, diuretics or beta-blockers. Captopril was added to these regimens at 25 mg twice daily in 3 patients, and 37.5 mg in 11 patients. Proteinuria decreased from 2.55±0.48 g/day to 1.58±0.35 g/day within three months after the start of administration. In 4 patients (28.6%), the extent of reduction was over 50%, and in 8 patients (57.1%), over 25%. Blood pressure, creatinine clearance and serum creatinine were not changed significantly. There was a positive linear correlation between the extent of reduction of proteinuria and the increase in plasma renin activity (r=0.93, p<0.001). We conclude that captopril reduces proteinuria in some patients with IgA nephritis whose plasma renin activity responds to the drug.

Journal

  • The Japanese Journal of Nephrology

    The Japanese Journal of Nephrology 35(8), 961-966, 1993

    Japanese Society of Nephrology

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