保存期慢性腎不全患者における凝固・線溶系に関する研究 慢性糸球体腎炎と糖尿病性腎症の比較

書誌事項

タイトル別名
  • Study on coagulation and fibrinolytic systems in predialysis patients with chronic renal failure. Comparison between patients with chronic glomerulonephritis and patients with diabetic nephropathy.
  • —Comparison between patients with chronic glomerulonephritis and patients with diabetic nephropathy—
  • ―慢性糸球体腎炎と糖尿病性腎症の比較―(多施設共同研究)

抄録

To clarify the abnormalities of coagulation and fibrinolytic systems in predialysis patients with chronic renal failure, we measured indices of coagulation and fibrinolytic systems in 33 predialysis patients whose creatinine (Cr) levels were over 3.0 mg/dl. We termed twenty-four patients with chronic glomerulonephritis the "CGN group". We also termed nine patients with diabetes mellitus the "DM group". We measured thrombin •antithrombin III complex (TAT), α2 plasmin inhibitor plasmin complex (PIC), D-dimer, protein C, protein S, thrombomodulin (TM), vitronectin, tissue plasminogen activator •plasminogen activator inhibitor-1 complex (tPAI-C) in these two groups. Furthermore, we measured the same indices after 6 months in the CGN group. As a result, the plasma levels of both TAT, PIC, TM/Cr ratio in the DM group were significantly higher than those in the CGN group. In the CGN group, changes in both protein S activities and plasma levels of tPAI-C were reduced significantly after 6 months. In conclusion, the abnormalities of coagulation and fibrinolytic systems in predialysis diabetic patients were stronger than those in predialysis patients with CGN. Furthermore, these abnormalities were worsened after 6 months in predialysis patients with chronic renal failure.

収録刊行物

詳細情報 詳細情報について

  • CRID
    1390282679834935424
  • NII論文ID
    130004170401
  • DOI
    10.14842/jpnjnephrol1959.39.474
  • ISSN
    18840728
    03852385
  • PubMed
    9283213
  • 本文言語コード
    ja
  • データソース種別
    • JaLC
    • PubMed
    • CiNii Articles
  • 抄録ライセンスフラグ
    使用不可

問題の指摘

ページトップへ