γグロブリン静注後も症状が進行し，続いて施行した免疫吸着療法後に劇的に症状が改善した重症Ｇｕｉｌｌａｉｎ‐Ｂａｒｒｅ症候群の７歳女児例

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  • Dramatic Improvement with Immunoabsorption Therapy in a 7-Year-Old Girl with Severe Guillain-Barre Syndrome after Unsuccessful Gammaglobulin Therapy.

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We report a 7-year-old girl with severe Guillain-B arre syndrome (GBS) who showed dramatic improvementa fter immunoabsorptionth erapy. She had progressivem uscle weaknessw ith resultant respiratory failure. On the 7th day of the illness, she was nearly quadriplegic and dependent on mechanical ventilation. In addition, she had autonomic manifestations, areflexia, abolished or delayed peripheral nerve conduction, and increased CSF protein. Administrationo f a high dose of gammaglobulin failed to improve the symptoms. Immunoabsorptionth erapy using a tryptophan column was performed9 times during 17 days. After 5 times of immunoabsorption therapy, the muscle weakness improved dramatically ; she was extubated 16 days after the institution of the therapy and walked without assistance on the 41st day. She regained normal muscle power without any sequelae. The immunoabsorption therapy caused hemolysis and decrease of serum fibrinogen, but no serious complications. The clinical course of this patient suggests the efficacy of immunoabsorption therapy in GBS.

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  • 脳と発達

    脳と発達 30 (3), 255-260, 1998

    THE JAPANESE SOCIETY OF CHILD NEUROLOGY

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