副作用軽減を目的とした再発卵巣癌・再発子宮頚癌に対するCPT‐11の間けつ的反復投与法の試み  [in Japanese] Clinical study of intermittent repetitive administration of CPT-11 for recurrent ovarian carcinoma and uterine cervical carcinoma. An attempt to reduce its side effects.  [in Japanese]

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Abstract

DNAトポイソメラーゼ1阻害剤CPT-11は,難治性再発卯巣癌,子宮頸癌に有効性が期待される新薬である.しかし白血球減少,下痢等の副作用の重篤さも報告され,使用は躊躇されがちである.当科では平成6年8月より難治性再発癌症例に本剤の使用を試みてきた.平成8年4月末現在,その症例は卵巣癌14例,子宮頸癌6例の計20例である.このうちの16例に副作用の軽減を主目的に投与量を初回70mg/m2から始め,10日間隔で漸次100mg/m2まで増量しながら,計9回投与を1コースとする反復投与を試みた.副作用の白血球減少と下痢は,ともにG3以上の重症例の著明な減少をみた.また効果面でも卵巣癌で10例中2例,子宮頸癌では6例中頸部腺癌1例を含む3例に有効性を認めた.〔産婦の進歩49(2);110--115,1997(平成9年3月)〕

CPT-11 was given to 14 patients with CDDP-resistant recurrent ovarian carcinoma and 6patients with radiotherapy-resistant uterine cervical carcinoma between August 1994 and April 1996. At first, CPT-11 was given to 4 ovarian carcinomas in the defined method A of 100 mg/m2/ week. However, the side effects of diarrhea and leukocytopenia were too severe to maintain the therapy. In an effort to reduce these side effects, a new administration method was devised: an initial dose of 70mg/m2 followed by increasing the dose to 100 mg/m2 every 10 days. Administrating the medication nine times in this method was defined as one course of therapy. This new method of administrating CPT-11 was practiced in the following 16 cases. It proved to be apparently helpful in reducing the previous side effects of diarrhea and leukocytopenia. Since both grade3 diarrhea and grade3 leukocytopenia were particularly reduced, we could smoothly treat every patient according to our schedule. In view of the anti-cancer effect, response was observed in 2 of 10 ovarian carcinomas, and 3 of 6 uterine cervical carcinomas inculuding 1adenocarcinoma. We could suggest that our new method of CPT-11 administration is clinically useful. [Adv Obstet Gynecol 49 (2); 110 115, 1997 (H9.3)]

Journal

  • ADVANCES IN OBSTETRICS AND GYNECOLOGY

    ADVANCES IN OBSTETRICS AND GYNECOLOGY 49(2), 110-115, 1997

    THE OBSTETRICAL GYNECOLOGICAL SOCIETY OF KINKI DISTRICT JAPAN

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