ホップ抽出物の育毛養毛効果  [in Japanese] Hop Extract as a New Potent Ingredient for air Growth Products.  [in Japanese]

Access this Article

Author(s)

Abstract

毛髪の成長は多くの要因によって複雑に制御されている。男性型脱毛症の原因のひとつとして男性ホルモンの作用が挙げられる。男性ホルモンであるテストステロンは5α-ReductaseによってDHTに変換され, さらにDHTがレセプターに結合することによってホルモン作用を発揮する。そこで我々は80種類の植物抽出液を調整し, この中から5α-Reductase阻害作用を示す成分のスクリーニングを行った。その結果ホップ抽出液が高い阻害作用を示すことがわかった。さらに, ホップ抽出液には培養毛根由来細胞の増殖を促進する作用が認められた。この抽出液を用いてマウスを用いた育毛養毛試験を行ったところ, ミノキシジルと同等の発毛促進作用を示した。また, ヒト頭髪に用いた場合には毛髪成長速度を促進する作用があることも認められた。<br>長期使用試験においても良好な結果が得られたことから, ホップ抽出液は有効な育毛養毛用化粧品原料であることが示された。

It is well known that hair growth is regulated by many factors. In the male pattern baldness, the hormonal effect due to androgens, such as testosterone (TE) and dihydrotestosterone (DHT), is the most important factor. TE is converted to an active androgen, DHT, by 5α-reductase. It has been considered that the DHT binding to androgen receptors expresses the hormonal effect. Therefore, we searched for active ingredents which possessed 5α-reductase inhibitory activity among 80 kinds of plant extracts. We found that Hop (<i>Humulus lupulus L.</i>) strongly inhibited the activity of 5α-reductase. Furthermore, it was found that Hop extract enhanced the proliferation of hair follicle derived keratinocyte. We demonstrated that Hop showed a potent stimulation of hair growth in the animal tests as well as Minoxidil. Hop extract gave the increase of the hair growth rate in human use test. Finally, the effect of the Hop extract was evaluated by using the 54 volunteers suffering from androgenetic alopecia. Most of the volunteers answered that the tonic was effetive in hair repairing.<br>We conclude that Hop extract is an excellent ingredient for hair growth products and that hair tonics containing Hop extract can benefit people suffering from androgenetic alopecia.

Journal

  • Journal of Society of Cosmetic Chemists of Japan

    Journal of Society of Cosmetic Chemists of Japan 29(4), 411-416, 1996

    The Society of Cosmetic Chemists of Japan

Codes

  • NII Article ID (NAID)
    130004188716
  • Text Lang
    JPN
  • ISSN
    0387-5253
  • Data Source
    J-STAGE 
Page Top