外科領域におけるEnduracidinの基礎的研究ならびに臨床使用成績

DOI Web Site

書誌事項

タイトル別名
  • LABORATORY AND CLINICAL STUDIES ON ENDURACIDIN IN SURGERY
  • ゲカ リョウイキ ニ オケル Enduracidin ノ キソテキ ケンキュウ ナラビニ リンショウ シヨウ セイセキ

この論文をさがす

抄録

On a new antibiotic substance, enduracidin, derived from Streptomycefsu ngicidicus, several basic experiments and clinical studies were performed in our clinic and the results were as follows.<BR>1) Serum levels: The serum levels of enduracidin after a single dose of 100 m g intramuscularly exhibited their peak at 6 to 8 hours, the value being about 1. 5 mcgiml. The serum levels were determinable even after 24 hours as high as about 1. 0 mcg/ml.<BR>2) Urinary excretions: 24 hours urinary e xcretion of enduracidin after 50 mg intramuscular administration were 1. 8% of the administered dosis. 3) Migration into the pus: Pus level from patient operated upon his liver rupture after a single dose of 100 mg intramuscularly was about 1/2 of serum level.<BR>4) Migration into the bile: Animal experiments wi th rabbits, 2. 5 to 3. 0 kg of body weight, were made by intramuscular injection of 20 mg/kg. The concentration of enduracidin in the bile average about 1/10 serum level.<BR>5) Organ level (determined by acetone-extraction method): The organ levels of rabbit following intramuscular injection of 20 mg per kilogram of body weight were found in kidney, spleen, liver, and muscle at 24 hours in order of higher concentration and gradually tended to increase in course of time respectively. The concentration in the muscles was generally low or not detectable, however concentration at the site of intramuscular injection kept longer period higher level than muscles elsewhere.<BR>6) Sensitivity of organisms clinically isolated: On Staphylococcal strains (80 strains) the peak sensitivity was observed at 0. 8 mcg/ml in 40% of all strains. MIC not higher than 1. 6 mcg/ml was recognized on 90% of all strains.<BR>7) Results of clin ical application: Enduracidin was found effective in 18 of 24 cases of surgical infection and ineffective in 5, uncertain in 1. The ineffective 2 cases were found in Gram-negativebacterial infections. A few side effects such as local pain were noted, but no disturbance of the renal or hepatic functions was found.

収録刊行物

詳細情報 詳細情報について

問題の指摘

ページトップへ