合成化学療法剤Piromidic acidに関する細菌学的研究

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  • BACTERIOLOGICAL STUDIES ON PIROMIDIC ACID, A NEW SYNTHETIC CHEMOTHERAPEUTICS
  • ゴウセイ カガク リョウホウザイ Piromidic acid ニ カンスル サイキンガクテキ ケンキュウ Piromidic acid ロンブン トクシュウゴウ

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Piromidic acid is a new synthetic chemotherapeutics developed at Research Laboratories of Dainippon Pharmaceutical Co. in 1970. In vitro and in vivo studies on the anti-microbial action of piromidic acid have been carried out and the following resullts were obtained : <BR>1) It was active primarily against gram-negative bacteria and Staphylococci.<BR>2) Cross-resistance was not observed between piromidic acid and antibiotics but observed between piromidic acid and nalidixic acid.<BR>3) The anti-microbial activity tended to increase when the pH of culture increased in relative acidity.<BR>4) Piromidic acid was apparently bactericidal in vitro at or above the minimal inhibitory concentration.<BR>5) In the studies with mice experimentally infected with Escherichia coli, piromidic acid and β-hydroxypiromidic acid showed the curative effects which were parallel with respective minimal inhibitory concentration values, their ED50 being found no more or less than that of nalidixic acid.

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