静注用PM-TC (プロリノメチルテトラサイクリン) の内科領域における基礎的ならびに臨床的検討

DOI Web Site

書誌事項

タイトル別名
  • LABORATORY AND CLINICAL INVESTIGATIONS ON PM-TC (PROLINOMETHYL TETRACYCLINE) FOR INTRAVENOUS INJECTION IN THE FIELD OF INTERNAL MEDICINE
  • ジョウチュウヨウ PM-TC プロリノメチルテトラサイクリン ノ ナイカ リョウイキ ニ オケル キソテキ ナラビニ リンショウテキ ケントウ

この論文をさがす

抄録

The laboratory and clinical investigations have been carried out on PM-TC (Prolinomethyl tetracycline) for intravenous injection, and the results were obtained as follows.<BR>1. The MIC (minimum inhibitory concentration) of PM-TC against Staphylococcus aureus and Escherichia coli is almost the same as that of TC, and the cross resistance was observed between the two antibiotics.<BR>2. The blood concentration of PM-TC for intravenous injection reached the peak 30 minutes after the administration, the value of PM-TC for intravenous injection being slightly higher than that of PRM-TC for intravenous injection.<BR>3. The recovery ratio into urine showed 39. 9% within 6 hours with PM-TC for intravenous injection, while 35. 9% with PRM-TC for intravenous injection.<BR>4. PM-TC for intravenous injection was administered to 12 cases of the infections in the field of internal medicine, and the high effective ratio was obtained as 83. 3%.<BR>5. Almost the same clinical effect was exhibited between the group administered PM-TC for intravenous injection and that administered PRM-TC for intravenous injection.<BR>6. As to the side-effect of PM-TC for intravenous injection, the patients complained of the abnormal sense in the mouth by the rapid intravenous injection, but the problem was little worth consideration by injecting slowly.<BR>7. The tests of hepatic and renal functions revealed no abnormal values which would be considered due to the administration of PM-TC for intravenous injection. From the above results, PM-TC for intravenous injection will be a useful antibiotic if the objects are selected properly. It may be recommended, however, that the antibiotic should be injected slowly to prevent the abnormal sense in the mouth.

収録刊行物

詳細情報 詳細情報について

問題の指摘

ページトップへ