Doxycycline (DOTC) の嫌気性菌に対する抗菌作用について

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タイトル別名
  • ANTIBACTERIAL ACTIVITY OF DOXYCYCLINE AGAINST ANAEROBES
  • Doxycyclne DOTC ノ ケンキセイキン ニ タイスル コウキン サヨウ ニ ツイテ

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The antimicrobial activity of doxycycline (DOTC) was determined against 157 strains of anaerobic bacteria mostly recent clinical isolates by a plate dilution method using GAM agar as culture medium. Seventy per-cent of the tested was inhibited by 25 mcg/ml or less of DOTC.<BR>The antimicrobial activity of DOTC was greater than that of oxytetracycline.<BR>While the antimicrobial activity was comparable among DOTC, aminobenzylpenicillin, cephalothin and lincomycin against Peptococcus and Peptostreptococcus, DOTC was only antibiotic which had the minimal inhibitory concentration of 25 mcg/ml or less against all strains of Bacteroides and Sphaerophorus.<BR>The results of the present investigations indicate as well as previous observations that DOTC has a favorable antimicrobial activity against all species of anaerobic organisms. This characteristics of DOTC may be advantageous for clinical therapy of infections due to anaerobic organisms.

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