Fosfomycinの嫌気性菌に対する抗菌力

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タイトル別名
  • SUSCEPTIBILITY OF ANAEROBES TO FOSFOMYCIN
  • Fosfomycin ノ ケンキセイキン ニ タイスル コウキンリョク

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Susceptibility of anaerobic bacteria isolated from clinical specimens to fosfomycin was studied by agar plate dilution technique.<BR>B. fragilis (24 strains) were resistant to 12. 5, μg/ml or more of this drug. Though 5 strains of Fusobacterium including F. nucleatum, F. russii and F. glutinosum were sensitive to 12.5, μg/ml or less of the drug, 14 strains of F. varium were resistant to 25 μg/ml or more.<BR>Five strains of Peptococcus were sensitive to 1.56μg/ml or less, 29 strains of Peptococcus, however, were resistant to 6.25, μg/ml or more.<BR>In addition, influence of this drug on anaerobes in human fecal flora was studied. By 4 days of administration of 1 g per day, predominant organisms in fecal flora were changed from B. fragilis ss. distasonis to B. fragillis ss. ovatus.

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