書誌事項
- タイトル別名
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- EXPERIMENTAL AND CLINICAL STUDIES ON MEZLOCILLIN
- Mezlocillin ノ キソテキ リンショウテキ ケントウ
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Mezlocillin, a new semisynthetic penicillin, has a wide spectrum of activity against gram-positive and gram-negative bacteria.<BR>Antimicrobial activity, concentration in blood and urinary excretion were studied.<BR>The values of minimal inhibitory concentration (MIC) obtained with mezlocillin against clinically isolated Pseudomonas aeruginosa range between 12.5 and 200 μg/ml.<BR>Antimicrobial activity of Mezlocillin against E. coli, Proteus mirabilis and indole-positive Proteus sp. is superior to carbenicillin by 1-3 dilution steps.<BR>After intravenous administration of 2g of mezlocillin serum concentrations of about 150 μg/ml were found after 15 minutes, and its half life is 40 to 49 minutes.<BR>Following the intravenous administration of 2g of mezlocillin, the urinary levels are 2000 to 4000 μg/ml in the 0 to 2 hour specimen, and urinary recovery rate in the 0 to 6 hour specimen is aobut 49%<BR>Twenty patients with complicated urinary trace infections received mezlocillin intravenously for five days, ten of them 2g of mezlocillin twice a day, and the other ten three times a day.<BR>Clinical response was found to be excellent in five cases, good in six and failure in nine. No significant difference of overall response between the two groups was observed.<BR>The original bacteria with MIC more than 100 μg/ml eliminated during therapy in two of the fourteen patients. On the contrary, all of those with MIC less than 100 μ/ml eliminated following administration of mezlocillin.<BR>None of the patients experienced any adverse reactions as a results of intravenous administration of mezlocillin during the present study, except increasing eosinophils in one case, bitter taste in one case and elevation of BUN value in another case.
収録刊行物
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- CHEMOTHERAPY
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CHEMOTHERAPY 27 (Supplement1), 265-280, 1979
公益社団法人 日本化学療法学会
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詳細情報 詳細情報について
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- CRID
- 1390001206281739648
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- NII論文ID
- 130004192536
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- NII書誌ID
- AN00186653
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- ISSN
- 18845894
- 00093165
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- NDL書誌ID
- 2077915
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- データソース種別
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- JaLC
- NDL
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可